Document Detail

Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran.
MedLine Citation:
PMID:  18728050     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants referred to a tertiary eye hospital during 2003-7 to provide preliminary evidence about ROP in Iran. METHODS: In a cross-sectional study, data for premature infants screened for ROP in Farabi Eye Hospital including possible risk factors and eye exams' results were recorded and analysed using chi(2), univariate and multiple regressions. Severe ROP was defined as ROP needing treatment or stage 4 or 5 of ROP. RESULTS: Among 953 premature infants, there were 329 (34.5%) different stages of ROP. Severe ROP was seen in 22.6% (215/953) of infants (16.5%: treatable, 6.1%: advanced untreatable). The mean gestational age (GA) and birth weight (BW) of infants with severe ROP were 28.8 (SD 2.4) weeks and 1256 (389) g respectively. Univariate analysis showed a significant relation between GA, BW, oxygen therapy, blood transfusion and ROP (p<0.001), while multiple-regression methods showed GA, BW and oxygen therapy as independent predictors of ROP (p<0.001, 0.019 and 0.033, respectively). CONCLUSION: The authors observed a relatively high incidence of ROP in this series, especially its severe form affecting relatively more mature infants, which merits further investigation. GA, BW and oxygen therapy were independent ROP determinants.
R Karkhaneh; S Z Mousavi; M Riazi-Esfahani; S A Ebrahimzadeh; R Roohipoor; M Kadivar; L Ghalichi; S F Mohammadi; M R Mansouri
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-26
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  92     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-27     Completed Date:  2008-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1446-9     Citation Subset:  IM    
Eye Research Centre, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Analysis of Variance
Blindness / prevention & control
Blood Transfusion / adverse effects
Cross-Sectional Studies
Infant, Newborn
Infant, Premature
Iran / epidemiology
Mass Screening
Ophthalmoscopy / methods
Oxygen Inhalation Therapy / adverse effects
Retinopathy of Prematurity / epidemiology*,  etiology
Risk Factors

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