Document Detail

Incidence and risk factors for multiple intracranial saccular aneurysms in patients with subarachnoid hemorrhage in Izumo City, Japan.
MedLine Citation:
PMID:  19669689     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A community-based study was conducted to estimate the incidence rates of multiple aneurysms and to investigate the factors related to multiplicity.
METHOD: The subjects were 291 patients with ruptured saccular aneurysms treated between 1980 and 1998, in Izumo, Japan. There were 403 aneurysms in total, and 78 patients (27%) had multiple aneurysms.
FINDINGS: Both the crude and the age- and sex-adjusted annual incidence rates per 100,000 population for multiple and single aneurysms were five and 14 for all ages, respectively, and were higher in women than in men. The age-specific incidence rates of both multiple and single aneurysms showed a tendency to increase with age. Of the 190 patients who underwent four-vessel studies, 26% (49) had multiple aneurysms. The frequencies of multiple aneurysms in patients with ruptured aneurysms > or =10 and <10 mm in diameter were 41% and 21%, respectively (p = 0.0081). In patients with multiple aneurysms, the number of aneurysms was greater in those with large ruptured aneurysms, and the unruptured aneurysms tended to be larger in patients with large ruptured aneurysms. The size of the ruptured aneurysms was positively associated with multiplicity, whereas hypertension had an inverse association. Age, sex, aneurysm site and risk factors other than hypertension were not predictive.
CONCLUSIONS: This study is the first to provide annual incidence rates for multiple aneurysms in a defined population. It appears that multiplicity of aneurysms is associated with larger ruptured aneurysms and that patients with larger ruptured aneurysms have a higher number of aneurysms as well as larger unruptured aneurysms.
Tetsuji Inagawa
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Publication Detail:
Type:  Journal Article     Date:  2009-08-11
Journal Detail:
Title:  Acta neurochirurgica     Volume:  151     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2011-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1623-30     Citation Subset:  IM    
Department of Neurosurgery, Araki Neurosurgical Hospital, Nishi-Ku, Hiroshima, Japan.
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MeSH Terms
Age Distribution
Aged, 80 and over
Cerebral Angiography
Cerebral Arteries / pathology*,  radiography
Intracranial Aneurysm / epidemiology*,  pathology*,  radiography
Japan / epidemiology
Middle Aged
Risk Factors
Severity of Illness Index
Sex Distribution
Subarachnoid Hemorrhage / epidemiology*,  pathology*,  radiography
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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