Document Detail


Incidence and risk factors for the growth of unruptured cerebral aneurysms: observation using serial computerized tomography angiography.
MedLine Citation:
PMID:  15597749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The goal of this study was to examine the growth of unruptured intracranial aneurysms with the focus on the risk factors and incidence of these lesions. METHODS: One hundred sixty-six untreated cerebral saccular aneurysms were analyzed in 140 patients. The age of the patients ranged from 29 to 82 years (mean 62.8 years), the female/male ratio was 94:46, and the mean follow-up period was 17.7 months. Aneurysms were located at the internal carotid artery (ICA) in 68 patients, the middle cerebral artery (MCA) in 43, the anterior cerebral artery in 38, the basilar artery (BA) in 13, and the vertebral artery in four patients. The maximum diameter of the lesions ranged from 2 to 20 mm (mean 4.1 mm). All patients were examined using serial computerized tomography angiography to evaluate signs of aneurysm growth. Although growth was identified in 10 aneurysms (nine patients 16.4%]), no bleeding occurred. Growth-related changes were significantly associated with the size of the aneurysm and occurred in three (2.4%) of 125 aneurysms measuring 2 to 4 mm, three (9.1%) of 33 lesions measuring 5 to 9 mm, and four (50%) of eight lesions measuring 10 to 20 mm. These changes were more frequently found in aneurysms located at the BA bifurcation (two [40%] of five lesions) and the ICA (six [8.8%] of 68 lesions) than in those located at the MCA (zero of 43 lesions, p < 0.05). The 1-, 2-, and 3-year cumulative growth rates calculated using the Kaplan-Meier method were 2.5, 8, and 17.6%, respectively. CONCLUSIONS: A diameter of at least 10 mm and a location at the BA bifurcation or the ICA were significant risk factors for aneurysm growth. The incidence of growth was 2.5% in the 1st year and this risk increased yearly. Computerized tomography angiography is useful for follow up of patients with aneurysms because it allows the detection of even subtle morphological changes.
Authors:
Shunji Matsubara; Hiromu Hadeishi; Akifumi Suzuki; Nobuyuki Yasui; Hiromi Nishimura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  101     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-15     Completed Date:  2005-01-03     Revised Date:  2005-10-04    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  908-14     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Basilar Artery / pathology,  radiography
Carotid Artery, Internal / pathology,  radiography
Cerebral Angiography*
Cerebral Hemorrhage / epidemiology
Female
Follow-Up Studies
Humans
Incidence
Intracranial Aneurysm / epidemiology*,  pathology,  radiography*
Male
Middle Aged
Middle Cerebral Artery / pathology,  radiography
Risk Factors
Rupture
Tomography, X-Ray Computed*
Vertebral Artery / pathology,  radiography
Comments/Corrections
Comment In:
J Neurosurg. 2005 Aug;103(2):390-1; author reply 391-2   [PMID:  16175874 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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