| Incidence and risk distribution of heart failure in adolescents and adults with congenital heart disease after cardiac surgery. | |
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MedLine Citation:
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PMID: 16616033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure (HF) is a major problem in the long-term follow-up of adults with congenital heart disease (CHD) after cardiac surgery. The purpose of this study was to evaluate risk factors for HF in patients with CHD. N-terminal-pro-brain natriuretic peptide and maximal oxygen uptake (VO2max) were measured in 345 consecutive patients with CHD. HF was defined as an elevated N-terminal-pro-brain natriuretic peptide level (> or = 100 pg/ml) and reduced VO2max (< or = 25 ml/kg/min). The HF criteria were met by 89 patients. These patients were significantly older (mean +/- SEM 30.8 +/- 0.9 vs 24.8 +/- 0.5 years), had significantly lower maximal heart rates (149 +/- 3 vs 164 +/- 1 beats/min), and had larger end-diastolic right ventricular diameters (36 +/- 1 vs 27 +/- 1 mm) and right ventricular pressure estimated by Doppler flow velocities of tricuspid valve regurgitation (2.9 +/- 0.1 vs 2.3 +/- 0.03 m/s). Mean fractional shortening of the left ventricle was within the normal range. To estimate risk stratification, odds ratios for HF were determined for the most frequently occurring types of congenital heart defects and surgical procedures. In conclusion, HF in adults with CHD predominately depends on diagnosis, age, the frequency of reoperation, and right ventricular function and may be related to chronotropic incompetence indicated by lower maximal heart rates. |
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Authors:
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Kambiz Norozi; Armin Wessel; Valentin Alpers; Jan Ole Arnhold; Siegfried Geyer; Monika Zoege; Reiner Buchhorn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-03 |
Journal Detail:
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Title: The American journal of cardiology Volume: 97 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-17 Completed Date: 2006-06-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1238-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatric Cardiology and Intensive Care Medicine, Medical School Hannover, Hannover, Germany. norozi.kambiz@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Biological Markers / blood Cardiac Surgical Procedures Diastole / physiology Echocardiography Exercise Test Female Heart Defects, Congenital / epidemiology, surgery* Heart Failure / blood*, epidemiology*, physiopathology Heart Ventricles / ultrasonography Humans Incidence Logistic Models Male Middle Aged Natriuretic Peptide, Brain / blood Oxygen Consumption / physiology Peptide Fragments / blood Prospective Studies Risk Assessment Ventricular Dysfunction, Right / epidemiology, physiopathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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