Document Detail


Incidence of red cell antibodies after multiple blood transfusion.
MedLine Citation:
PMID:  2378025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective study was performed to estimate the frequency of alloimmunization against red cell (RBC) antigens in a multiply transfused group. Patients (n = 186) were studied who had received at least six blood transfusions during a period of at least 3 months. Some 6944 units of blood were transfused. One hundred forty patients had hematologic disorders. The patients' sera were investigated every 3 months with indirect antiglobulin tests and enzyme-treated RBCs. Twenty-two patients (11.8%) made 33 antibodies. Seven patients made more than one antibody. Eight of the 22 patients (36.4%) made their first antibody before or at the 10th transfusion. The risk of immunization increased with the number of transfusions. Influence of gender and age was not demonstrable. Nor was a relationship demonstrated between blood transfusion reactions and RBC antibody formation; no delayed hemolytic transfusion reactions occurred. Anti-E was demonstrated in 12 patients and anti-K in 15. When the gene frequencies were taken into account, it appeared that anti-E was made by 11.5 percent of E-negative patients, most of whom were immunized after an estimated three transfusions with E-positive blood. Anti-K was made by 8.7 percent of the K-negative patients, after an estimated 2.1 units of K-positive blood. It might be desirable to match red cell units for the E and K antigens in patients at relatively high risk. These are primarily patients who have already formed an antibody and are going to receive many transfusions and women of childbearing age who are to receive more than 4 units of blood.
Authors:
C R Fluit; V A Kunst; A M Drenthe-Schonk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  30     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-5     Citation Subset:  IM    
Affiliation:
Blood Transfusion Service, St. Radboud University Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Antibody Formation
Blood Group Antigens / immunology*
Blood Transfusion*
Humans
Isoantibodies / analysis*
Retrospective Studies
Time Factors
Chemical
Reg. No./Substance:
0/Blood Group Antigens; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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