Document Detail

Incidence of red cell antibodies after multiple blood transfusion.
MedLine Citation:
PMID:  2378025     Owner:  NLM     Status:  MEDLINE    
A retrospective study was performed to estimate the frequency of alloimmunization against red cell (RBC) antigens in a multiply transfused group. Patients (n = 186) were studied who had received at least six blood transfusions during a period of at least 3 months. Some 6944 units of blood were transfused. One hundred forty patients had hematologic disorders. The patients' sera were investigated every 3 months with indirect antiglobulin tests and enzyme-treated RBCs. Twenty-two patients (11.8%) made 33 antibodies. Seven patients made more than one antibody. Eight of the 22 patients (36.4%) made their first antibody before or at the 10th transfusion. The risk of immunization increased with the number of transfusions. Influence of gender and age was not demonstrable. Nor was a relationship demonstrated between blood transfusion reactions and RBC antibody formation; no delayed hemolytic transfusion reactions occurred. Anti-E was demonstrated in 12 patients and anti-K in 15. When the gene frequencies were taken into account, it appeared that anti-E was made by 11.5 percent of E-negative patients, most of whom were immunized after an estimated three transfusions with E-positive blood. Anti-K was made by 8.7 percent of the K-negative patients, after an estimated 2.1 units of K-positive blood. It might be desirable to match red cell units for the E and K antigens in patients at relatively high risk. These are primarily patients who have already formed an antibody and are going to receive many transfusions and women of childbearing age who are to receive more than 4 units of blood.
C R Fluit; V A Kunst; A M Drenthe-Schonk
Related Documents :
15828925 - Granulocyte transfusions in children with chronic granulomatous disease and invasive as...
20639625 - Hemoglobin h disease in guangxi province, southern china: clinical review of 357 patients.
20496335 - Sickle cell chronic lung disease among young adult nigerians.
6838365 - Incidence and function of residual splenic tissue following splenectomy for trauma in a...
14707865 - Airway-centered interstitial fibrosis: a distinct form of aggressive diffuse lung disease.
10625265 - Cross sectional study of reporting of epileptic seizures to general practitioners.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  30     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-5     Citation Subset:  IM    
Blood Transfusion Service, St. Radboud University Hospital, Nijmegen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibody Formation
Blood Group Antigens / immunology*
Blood Transfusion*
Isoantibodies / analysis*
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Blood Group Antigens; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  HLA class I and II antigen phenotypes of North American Indians from Minnesota: implications for mar...
Next Document:  The late results of a trabeculoretraction operation