Document Detail

Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction.
MedLine Citation:
PMID:  14697459     Owner:  NLM     Status:  MEDLINE    
Contractile function in patients with ischemic left ventricular (LV) dysfunction may improve after myocardial revascularization. Currently, the incidence of contractile function recovery after revascularization in these patients is unclear. The aim of this study was to assess the incidence of function improvement after myocardial revascularization in patients with ischemic LV dysfunction. A total of 258 consecutive patients (aged 59 +/- 12 years) with severely depressed LV ejection fractions (EFs) due to chronic coronary artery disease and heart failure symptoms were studied. All patients underwent radionuclide ventriculography and 2-dimensional echocardiography at rest before and 3 to 6 months after revascularization. At baseline, 1,330 segments (32%) were normal and 2,775 segments (68%) were dysfunctional. Improvement after revascularization occurred in 736 of the 2,775 dysfunctional segments (27%). Overall, LVEF improved from 29 +/- 7 to 32 +/- 9 (p <0.0001). A clinically significant improvement of LVEF (>/=5% postrevascularization) was present in 101 patients (39%). Improvement of LVEF after revascularization was frequently observed in patients with a more severely impaired baseline LVEF. At least 3 segments with improvement of function were needed for an improvement of LVEF of >/=5%.
Arend F L Schinkel; Don Poldermans; Jean-Louis J Vanoverschelde; Abdou Elhendy; Eric Boersma; Jos R T C Roelandt; Jeroen J Bax
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  93     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-7     Citation Subset:  AIM; IM    
Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Coronary Artery Disease / epidemiology,  physiopathology*,  radionuclide imaging,  surgery,  ultrasonography
Middle Aged
Myocardial Contraction / physiology*
Myocardial Revascularization*
Netherlands / epidemiology
Radionuclide Ventriculography
Treatment Outcome
Ventricular Dysfunction, Left / physiopathology*,  radionuclide imaging,  ultrasonography

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