Document Detail

Incidence of psychiatric side effects during pegylated interferon- alpha retreatment in nonresponder hepatitis C virus-infected patients.
MedLine Citation:
PMID:  17845538     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Evaluate the incidence of mental disorders using pegylated interferon plus ribavirin retreatment in nonresponder hepatitis C virus-infected patients. METHOD: The Mini-International Neuropsychiatric Interview (MINI) was used to evaluate 30 hepatitis C virus-infected interferon-nonresponder patients at baseline and following 4, 12 and 24 weeks of pegylated interferon retreatment. RESULTS: During the pegylated interferon/ribavirin retreatment, 5(16.6%) patients developed psychiatric side effects: 3(10%) were diagnosed with major depressive disorder, 1(3.3%) had a brief psychotic disorder and 1(3.3%) presented with panic attacks. CONCLUSION: This is the first prospective study evaluating the incidence of neuropsychiatric side effects during interferon retreatment of hepatitis C virus-infected patients, suggesting that the risk of acquiring serious psychiatric symptoms during retreatment with interferon-alpha (IFN-alpha) may not be higher than during the first antiviral therapy. This finding challenges the hypothesis that during a second treatment with IFN-alpha, patients with hepatitis C may be at greater risk for neuropsychiatric side effects than naïve patients.
Lucas C Quarantini; Rodrigo A Bressan; Amanda Galvão; Susana Batista-Neves; Raymundo Paraná; Angela Miranda-Scippa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  27     ISSN:  1478-3223     ISO Abbreviation:  Liver Int.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1098-102     Citation Subset:  IM    
University Hospital, Federal University of Bahia School of Medicine, Salvador-Bahia, Brazil.
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MeSH Terms
Anti-Anxiety Agents / therapeutic use
Antidepressive Agents / therapeutic use
Antipsychotic Agents / therapeutic use
Antiviral Agents / adverse effects*
Depressive Disorder, Major / chemically induced*,  drug therapy,  epidemiology
Drug Therapy, Combination
Hepatitis C / drug therapy*
Interferon Alfa-2a / adverse effects*
Interferon Alfa-2b / adverse effects*
Middle Aged
Panic Disorder / chemically induced*,  drug therapy,  epidemiology
Polyethylene Glycols / adverse effects*
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders / drug therapy,  epidemiology,  etiology*
Ribavirin / adverse effects*
Risk Assessment
Risk Factors
Time Factors
Treatment Failure
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Antiviral Agents; 0/Polyethylene Glycols; 0/peginterferon alfa-2a; 0/peginterferon alfa-2b; 36791-04-5/Ribavirin; 76543-88-9/Interferon Alfa-2a; 99210-65-8/Interferon Alfa-2b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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