Document Detail


Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders.
MedLine Citation:
PMID:  14516144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The majority of cross-sectional studies have shown a higher prevalence of ventilatory impairment in welders while only few longitudinal studies were able to detect chronic effects on spirometry or bronchial responsiveness. The aim of the study was to determine the incidence of probable occupational asthma (OA), bronchial obstruction and hyperresponsiveness among 286 students entering an apprenticeship programme in the welding profession. This epidemiological prospective cohort study consisted of a baseline assessment survey and two follow-up assessments. A respiratory symptom questionnaire was administered at each visit. Spirometry and methacholine bronchial challenge test results, conducted once prior to onset of exposure and later after an average of 15 months of apprenticeship, were available for 194 subjects. The incidence of probable OA was approximately 3% (6 of 194). The incidence of bronchial hyperresponsiveness, defined as a > or = 3.2-fold decrease in the provocative concentration causing a 20% fall in the forced expiratory volume in one second from baseline to the end of the study was 11.9%. A statistically significant difference was found between the baseline and end of study for the lung function values. In particular, the forced expiratory volume per cent predicted had significantly dropped by 8.4% on average. The significance of these early pulmonary function changes in relation to possible chronic effects of exposure to welding fumes and gases remains to be explored.
Authors:
M El-Zein; J L Malo; C Infante-Rivard; D Gautrin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  22     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2004-01-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Affiliation:
Joint Depts of Epidemiology and Biostatistics and Occupational Health, McGill University, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / epidemiology*,  etiology,  physiopathology
Bronchial Hyperreactivity / etiology,  physiopathology*
Bronchial Provocation Tests
Cohort Studies
Cross-Sectional Studies
Female
Forced Expiratory Volume
Humans
Incidence
Male
Occupational Diseases / epidemiology*,  physiopathology
Occupational Exposure / adverse effects
Prospective Studies
Questionnaires
Respiratory Tract Diseases / epidemiology*,  etiology,  physiopathology
Spirometry
Time Factors
Welding

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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