Document Detail

Incidence and prevention of thrombosis of the subclavian vein during total parenteral nutrition.
MedLine Citation:
PMID:  6808679     Owner:  NLM     Status:  MEDLINE    
In this study, we were able to document by radionuclide venogram the presence of thrombosis of the subclavian vein in seven of 22 patients receiving standard total parenteral infusions. By adding 3,000 U.S.P. units of heparin to each liter of infusate, we were able to reduce the number of instances of thrombosis to two in 24 patients. Although none of the patients in the heparin therapy group experienced laboratory or clinical manifestations of anticoagulation, we suggest that further studies be done to investigate the reduced heparin concentrations to determine the lowest effective level. Based upon these observations, we currently recommend that 3,000 U.S.P. units of heparin be added to each liter of total parenteral nutrition solution infused through a subclavian venous catheter.
P J Fabri; J M Mirtallo; R L Ruberg; K A Kudsk; D A Denning; E C Ellison; P Schaffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  155     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-40     Citation Subset:  AIM; IM    
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MeSH Terms
Heparin / therapeutic use*
Middle Aged
Parenteral Nutrition / adverse effects*
Parenteral Nutrition, Total / adverse effects*
Prospective Studies
Random Allocation
Subclavian Vein* / radionuclide imaging
Thrombosis / etiology,  prevention & control*,  radionuclide imaging
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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