Document Detail


Incidence and prevention of supraventricular tachyarrhythmias after coronary bypass surgery.
MedLine Citation:
PMID:  3539826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Supraventricular tachyarrhythmias are a frequent complication encountered after coronary artery bypass grafting. A retrospective survey of 102 consecutive patients undergoing exclusive bypass grafting at St. Mary's Hospital supplemented by a review of 16 published reports over a period of 10 years revealed a mean incidence of post-operative tachyarrhythmia of 33.4% in 1344 patients (range 11.4-100%). One hundred and thirty two patients undergoing exclusive bypass surgery, were randomised prospectively in double blind fashion to receive either oral timolol or matched placebo approximately 24 hours after surgery. In the 66 patients receiving timolol, there was a significant reduction of post-operative arrhythmias compared to the 66 patients receiving placebo: from 19.7 to 7.5% (P less than 0.05). Of all arrhythmias, two thirds appeared under 48 hours after surgery. In the timolol group, 4 patients developed systemic hypotension. This was readily reversed by withdrawing the drug. No other side effects were noted. The use of oral timolol after coronary artery surgery significantly lowers the incidence of post-operative supraventricular arrhythmias.
Authors:
R J Vecht; E P Nicolaides; J K Ikweuke; C Liassides; J Cleary; W B Cooper
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  13     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-01-27     Completed Date:  1987-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Coronary Artery Bypass*
Double-Blind Method
Female
Humans
Male
Middle Aged
Postoperative Complications
Prospective Studies
Random Allocation
Tachycardia, Supraventricular / etiology*,  prevention & control
Timolol / therapeutic use*
Chemical
Reg. No./Substance:
26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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