Document Detail


Incidence and prevalence of dermatitis herpetiformis in a country in central Sweden, with comments on the course of the disease and IgA deposits as diagnostic criterion.
MedLine Citation:
PMID:  6203303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a defined area of 273 000 inhabitants in Central Sweden a total number of 125 patients with dermatitis herpetiformis (DH) were observed during the years 1974-1982. The incidence was calculated for the years 1943-1982 and was found to be 0.86-1.45 patients/100 000 inhabitants/year, which is in agreement with a report from Finland. However, the prevalence of DH in the area was 39.2 patients/100 000 inhabitants, which is much higher than previously reported. Spontaneous transient remissions of more than half a year duration were seen in 20% of the patients. At the end of the study, 16 out of 37 patients (43%) on normal diet used no dapsone because of no or minimal rash. Immunohistochemical demonstration of IgA-deposits at the dermoepidermal junction was found to be a good diagnostic criterion. Granular deposits were seen in all except one patient, also in those needing no dapsone. Five out of 6 patients with a granular-linear pattern were still alive at the end of the study, and all of them needed dapsone for control of the rash.
Authors:
H Moi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  64     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  144-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Dapsone / therapeutic use
Dermatitis Herpetiformis / drug therapy,  epidemiology*,  immunology
Diet Therapy
Female
Fluorescent Antibody Technique
Glutens
Humans
Immunoglobulin A / analysis*
Male
Middle Aged
Skin / immunology
Sweden
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 80-08-0/Dapsone; 8002-80-0/Glutens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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