| Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis. | |
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MedLine Citation:
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PMID: 21284715 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants less than 12 months of age experiencing their first episode of bronchiolitis. Methods: Epidemiologic, clinical and virologic data were prospectively collected. Severity was assessed by the need for ventilatory support. Results: Of the 310 infants enrolled, 16 (5.1%) presented with severe bronchiolitis requiring ventilatory support (11 since admission). Compared with infants with less severe bronchiolitis, infants with severe disease presented with lower birth weight, gestational age, postnatal weight, and postnatal age, and were more likely to be born by cesarean section. C-reactive protein positive results (>0.8 mg/dl) and pulmonary consolidation on chest x ray were more common among infants with severe disease. Severity was independently associated with younger age on admission < 30 days, respiratory syncytial virus (RSV) infection and lymphocyte counts < 3200/μl. No significant differences were found between epidemiologic variables. Conclusions: Severe bronchiolitis is uncommon in previously healthy term infants less than 12 months of age and when present develops soon after disease onset. Severity is predicted by young age and RSV carriage, whereas epidemiologic variables seem less likely to intervene. Key words: bronchiolitis, mechanical ventilation, non invasive ventilation, pediatric intensive care unit, previously healthy term infants, respiratory viruses, risk factors. |
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Authors:
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Paola Papoff; Corrado Moretti; Giulia Cangiano; Enea Bonci; Mario Roggini; Alessandra Pierangeli; Carolina Scagnolari; Guido Antonelli; Fabio Midulla |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Pediatric Emergency and Intensive Care, Department of Pediatrics Virology Section, Department of Experimental Medicine Pediatric Radiology, Department of Pediatrics Biostatistics, Department of Pediatrics, Sapienza University of Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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