| Incidence, predictors and prognostic importance of bleeding after primary PCI for ST-elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 20542805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate incidence, predictors and prognosis of bleeding in ST elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: A large scale, prospective, observational study was performed between 1991 and 2004 in a single teaching hospital in The Netherlands including all consecutive STEMI patients who underwent primary PCI. The independent association between both major and minor bleeding and one year mortality was evaluated using Cox proportional hazard models. A total of 5,030 patients were included, of whom 109 patients (2%) had cardiac surgery within 48 hours. Data on bleeding <48 hours were available in 4,717 patients (96%). Of these, 80 (1.6%) had major bleeding, whereas minor bleeding was observed in 266 patients (5.6%). Independent predictors of minor bleeding were advanced age, multivessel disease, Killip class > or = 2 on admission, anterior MI location and TIMI 0 flow before PCI. Killip class > or = 2 on admission was an independent predictor of major bleeding. Major bleeding (HR 3.5 [95% CI 2.3-5.4]) was associated with an increased risk of death at one year. CONCLUSIONS: After primary PCI, the incidence of major bleeding is less than 2%. Although relatively infrequent, major bleeding complications are strongly and independently related to short- and midterm mortality. |
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Authors:
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Renicus S Hermanides; Jan-Paul Ottervanger; Jan-Henk E Dambrink; Menko-Jan de Boer; Jan C A Hoorntje; A T Marcel Gosselink; Harry Suryapranata; Arnoud W J van 't Hof |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: 6 ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: France |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Isala klinieken, Location Weezenlanden, Department of Cardiology, Zwolle, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*, mortality Anticoagulants / adverse effects Chi-Square Distribution Female Hemorrhage / etiology*, mortality Hospitals, Teaching Humans Incidence Kaplan-Meiers Estimate Logistic Models Male Middle Aged Myocardial Infarction / therapy* Netherlands Platelet Aggregation Inhibitors / adverse effects Proportional Hazards Models Prospective Studies Registries Risk Assessment Risk Factors Severity of Illness Index Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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