Document Detail


Incidence and predictors of glaucoma following surgery for congenital cataract in the first year of life in Victoria, Australia.
MedLine Citation:
PMID:  23332011     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: To determine the incidence and predictors of glaucoma following surgery for congenital and infantile cataract in an Australian population DESIGN: Retrospective cohort study PARTICIPANTS: Infants (age <12 months) during lens extraction between January 1992 and May 2006, from two tertiary referral centres METHODS: Children with uveitis, anterior segment dysgenesis, aniridia, retinopathy of prematurity, and lens subluxation were excluded. Potential predictors of incident glaucoma were examined using Cox proportional hazards regression with adjustment for clustering between eyes. MAIN OUTCOME MEASURES: Incidence and predictors of secondary glaucoma RESULTS: 147 eyes of 101 patients (46 bilateral cataract; 55 unilateral cataract) were included, with median follow-up of 9.9 years (range 1.2 - 18.9 years). Cumulative incidence of glaucoma was 32.0% for eyes (N=47) and 30.7% (N=31) for subjects. Incidence was higher in children with bilateral cataract (38.9 vs. 17.1%, P=0.004). There were 3.9 cases of glaucoma per 100 person years of follow-up, and the incidence rate was highest for surgery performed in the first month of life. Children with glaucoma had longer median follow-up (11.8 vs. 9.3 years, P=0.005). Risk of glaucoma decreased with increasing months of age at operation: hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.69 - 0.91, P=0.001. Median visual acuity was worse in children with unilateral cataract (P<0.001) CONCLUSIONS: We identified an increased risk of glaucoma when cataract surgery was performed in younger infants, and in those with bilateral cataract. As glaucoma may develop over a decade following lens extraction, all patients require life-long surveillance following cataract surgery to prevent glaucoma-associated vision loss.
Authors:
Jonathan B Ruddle; Sandra E Staffieri; Jonathan G Crowston; Justin C Sherwin; David A Mackey
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Clinical and Experimental Ophthalmology © 2013 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation:
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Integrative modelling of pH-dependent enzyme activity and transcriptomic regulation of the acetone-b...
Next Document:  Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with ...