Document Detail


Incidence of penicillinase producing Neisseria gonorrhoeae (PPNG) strains and susceptibility of gonococcal isolates to antibiotics in Benin City, Nigeria.
MedLine Citation:
PMID:  3936776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 53 strains of Neisseria gonorrhoeae isolated in Benin City, Nigeria, in February 1983 to October 1984, 46 (87%) produced penicillinase. The minimum inhibitory concentrations (MICs) of penicillin G and ampicillin for these isolates were between 1 mg/l and and 50 mg/l. About 48% (22/46) of the penicillinase producing strains were also resistant to streptomycin, cotrimoxazole, and ampicillin and cloxacillin. All 53 isolates were sensitive to tetracycline, erythromycin, amoxycillin and clavulanic acid, nalidixic acid, spectinomycin, and the penicillinase stable cephalosporins. The high incidence of resistance may have been the result of indiscriminate and unsupervised use of antibiotics before patients presented for proper treatment in clinics and hospitals.
Authors:
E E Obaseiki-Ebor; S M Oyaide; E E Okpere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genitourinary medicine     Volume:  61     ISSN:  0266-4348     ISO Abbreviation:  Genitourin Med     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-26     Completed Date:  1986-02-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8503853     Medline TA:  Genitourin Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ampicillin / pharmacology
Anti-Bacterial Agents / pharmacology*
Clavulanic Acid
Clavulanic Acids / pharmacology
Humans
Male
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects,  enzymology,  isolation & purification*
Nigeria
Penicillinase / biosynthesis
Tetracycline / pharmacology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Clavulanic Acids; 58001-44-8/Clavulanic Acid; 60-54-8/Tetracycline; 69-53-4/Ampicillin; EC 3.5.2.-/Penicillinase
Comments/Corrections

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