Document Detail

Incidence of paroxysmal atrial tachycardias in patients treated with cardiac resynchronization therapy and continuously monitored by device diagnostics.
MedLine Citation:
PMID:  19864311     Owner:  NLM     Status:  MEDLINE    
AIMS: Little is known about the incidence of paroxysmal atrial tachycardias (PAT) in patients with heart failure (HF). The availability of cardiac resynchronization therapy (CRT) devices with extended diagnostics for AT enables continuous monitoring of PAT episodes. The aim of the study was to assess the incidence over time of PAT in HF patients treated with CRT. METHODS AND RESULTS: Consecutive patients in NYHA functional class III or IV despite optimal drug therapy, QRS duration > or = 130 ms, left ventricular ejection fraction < or = 35%, and left ventricular end-diastolic dimension > or = 55 mm were eligible for enrolment. Patients with permanent or persistent atrial fibrillation (AF) were not included in the study. The first follow-up examination was performed 2 weeks after implantation, to optimize atrial sensing and CRT. Subsequent follow-up examinations were carried out 15 and 28 weeks after implantation, to collect the telemetric data. A total of 173 patients (67 +/- 11 years, M 116) were enrolled. Complete arrhythmia monitoring data were available from 120 patients over a mean follow-up of 183 +/- 23 days. Atrial tachycardia episodes were detected through telemetry in 25 of 120 patients (21%) during at least one follow-up examination. Atrial tachycardia episodes were recorded in 29 and 17% (P = NS) of patients with and without previous history of AF, respectively. CONCLUSION: More than 20% of the overall HF patient population treated with CRT suffer PAT episodes. Paroxysmal atrial tachycardia may interfere with response to CRT. Therefore, telemetric data may be relevant to drive the appropriate therapy in each patient.
C Leclercq; L Padeletti; R Cih?k; P Ritter; G Milasinovic; D Gras; V Paul; I C Van Gelder; C Stellbrink; G Rieger; G Corbucci; B Albers; J C Daubert;
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  12     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-7     Citation Subset:  IM    
H?pital P?ntchaillou CHU, University of Rennes, Rennes, France.
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MeSH Terms
Atrial Fibrillation / diagnosis,  epidemiology*,  prevention & control*
Cardiac Pacing, Artificial / utilization*
Electrocardiography, Ambulatory / utilization*
Europe / epidemiology
Heart Failure / diagnosis,  epidemiology*,  prevention & control*
Risk Assessment / methods
Risk Factors
Treatment Outcome
Comment In:
Europace. 2010 Jan;12(1):9-10   [PMID:  20008493 ]

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