| Incidence, outcome, and long-term consequences of herpes simplex virus type 1 reactivation presenting as a facial rash in intubated adult burn patients treated with acyclovir. | |
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MedLine Citation:
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PMID: 12131395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increased mortality, extensive visceral involvement, and necrotizing tracheobronchitis associated with herpes viruses have been reported after burns. It is unclear whether herpes presenting as a facial rash results in outcome changes after burns. METHODS: A retrospective study characterizing the incidence, presentation, and outcome of 14 patients with facial herpes rashes out of 95 severely burned intubated adults was performed. RESULTS: Facial rashes attributed to herpetic infections were found in at least 15% of patients. The problem was recognized during the second week after burn. There was no difference in mortality or length of stay noted between patients with or without the infection. CONCLUSION: The course of this infection was relatively benign in this group of acyclovir-treated patients. Even so, the lesions clearly contributed to patient discomfort and often produced fevers requiring costly investigations. Early recognition could help prevent diffuse spread of the lesions, decreasing patient discomfort and improving patient care. |
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Authors:
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Philip E Fidler; Bonnie T Mackool; David A Schoenfeld; Maryanne Malloy; John T Schulz; Robert L Sheridan; Colleen M Ryan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 53 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2002-12-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 86-9 Citation Subset: AIM; IM |
Affiliation:
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Sumner Redstone Burn Center, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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therapeutic use* Adult Aged Antiviral Agents / therapeutic use* Body Surface Area Boston / epidemiology Burn Units Burns / classification, complications*, therapy Facial Dermatoses / drug therapy*, epidemiology, etiology*, virology Herpes Simplex / drug therapy*, epidemiology, etiology*, virology Herpesvirus 1, Human / physiology* Hospitals, General Humans Incidence Intubation, Intratracheal* / adverse effects* Length of Stay / statistics & numerical data Middle Aged Retrospective Studies Survival Analysis Treatment Outcome Virus Activation* |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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