| Incidence, origin, and character of cerebral injury in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery. | |
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MedLine Citation:
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PMID: 16647903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the study was to determine the incidence, origin, and character of cerebral lesions in monochorionic twins with twin-to-twin transfusion syndrome treated with fetoscopic laser surgery. STUDY DESIGN: This was a prospective study of monochorionic twins with twin-to-twin transfusion syndrome treated with fetoscopic laser surgery and monochorionic twins without twin-to-twin transfusion syndrome delivered at our center between June 2002 and September 2005, using cranial ultrasonography. RESULTS: Incidence of antenatally acquired severe cerebral lesions in the twin-to-twin transfusion syndrome group was 10% (8/84) and 2% (2/108) in the non-twin-to-twin transfusion syndrome group (P = .02). Incidence of severe cerebral lesions at discharge was 14% (12/84) in the twin-to-twin transfusion syndrome group and 6% (6/108) in the non-twin-to-twin transfusion syndrome group (P = .04). Antenatal injury was responsible for severe cerebral lesions in 67% (8/12) of the twin-to-twin transfusion syndrome group. CONCLUSION: Incidence of severe cerebral lesions in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery is high and results mainly from antenatal injury. |
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Authors:
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Enrico Lopriore; Gerda van Wezel-Meijler; Johanna M Middeldorp; Marieke Sueters; Frank P Vandenbussche; Frans J Walther |
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Publication Detail:
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Type: Journal Article Date: 2006-04-21 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 194 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-01 Completed Date: 2006-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1215-20 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. e.lopriore@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Injuries
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epidemiology*,
etiology*,
ultrasonography Female Fetofetal Transfusion / surgery* Fetoscopy* Humans Incidence Infant, Newborn Laser Therapy / adverse effects* Netherlands / epidemiology Pregnancy Prospective Studies Twins, Monozygotic |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2007 Apr;196(4):e14; author reply e14-5
[PMID:
17403389
]
Am J Obstet Gynecol. 2006 May;194(5):1208-10 [PMID: 16579947 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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