Document Detail

Incidence of ocular morbidity among multibacillary leprosy patients during a 2 year course of multidrug therapy.
MedLine Citation:
PMID:  16622085     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the incidence of and risk factors for ocular complications in multibacillary (MB) leprosy patients during their 2 year, fixed duration, multidrug therapy (MDT).
METHODS: Periodic eye examinations were conducted prospectively on a cohort of 301 consecutive newly diagnosed MB patients every 6 months during their 2 year course of MDT. Incidence of ocular pathology was calculated as the number of events per person year of event free follow up of patients who did not have the specific finding at baseline.
RESULTS: 292 (97%) patients had one or more follow up visits. The incidence of lagophthalmos was 1.2%/patient year (95% CI 0.5% to 2.8%); corneal opacity was 7.4%/patient year (95% CI 5.1% to 10.6%); uveal involvement was 5.1%/patient year (95% CI 3.3% to 7.8%), and cataract that reduced vision to 6/18 or less was seen in 4.3%/patient year (95% CI 2.7% to 6.9%) of patients. Overall, 23 individuals (5.8%/patient year, 95% CI 3.9 to 8.8) developed leprosy related potentially blinding pathology during the 2 years of MDT.
CONCLUSIONS: Approximately 20% of patients with MB leprosy can be expected to develop ocular complications of leprosy during a 2 year course of MDT, many (11%) of which are potentially vision threatening. Ophthalmological monitoring to detect and treat ocular complications at defined intervals during MDT is indicated.
E Daniel; T J Ffytche; P S S Sundar Rao; J H Kempen; M Diener-West; P Courtright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  90     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-19     Completed Date:  2006-06-19     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
Schieffelin Leprosy Research and Training Centre, Vellore, India.
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MeSH Terms
Age Factors
Bacteriological Techniques
Drug Therapy, Combination
Eye Diseases / diagnosis,  microbiology*
Leprostatic Agents / therapeutic use*
Leprosy / complications*,  drug therapy,  microbiology
Proportional Hazards Models
Prospective Studies
Risk Assessment
Time Factors
Reg. No./Substance:
0/Leprostatic Agents
Comment In:
Br J Ophthalmol. 2006 May;90(5):528-9   [PMID:  16622080 ]

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