Document Detail


Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era.
MedLine Citation:
PMID:  19188649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate highly active antiretroviral therapy (HAART)-era incident rates for the first episode of noninfectious conditions in human immunodeficiency virus (HIV)-infected youth in order to identify HAART-era changes in the natural history of perinatal HIV infection.
DESIGN: Multicenter prospective cohort study.
SETTING: More than 80 sites in the United States including Puerto Rico.
PATIENTS: Perinatally HIV-infected youth.
MAIN OUTCOME MEASURES: Incidence rates (IRs) per 100 person-years were calculated for targeted noninfectious conditions occurring in perinatally HIV-infected children. A chi(2) test for linear trend was used to evaluate changes in the rates from 2001 to 2006.
RESULTS: Two thousand five hundred seventy-five perinatally HIV-infected children (51%, female; 59%, black, non-Hispanic) were enrolled in Pediatric AIDS Clinical Trials Group (PACTG) 219C between 2000 and 2006 and were followed up for a median of 59 months. The 10 most common noninfectious conditions were pregnancy conditions (IR = 6.16; 95% confidence interval (CI), 3.9-9.3), birth defects (IR = 0.19; 95% CI, 0.1-0.3), gynecological dysplasias (IR = 5.92; 95% CI, 3.9-8.6), condyloma (IR = 0.15; 95% CI, 0.1-0.2), encephalopathy (IR = 0.38; 95% CI, 0.3-0.5), pancreatitis (IR = 0.30; 95% CI, 0.2-0.4), cardiac disorders (IR = 0.28; 95% CI, 0.2-0.4), renal disorders (IR = 0.26; 95% CI, 0.2-0.4), peripheral neuropathy (IR = 0.23; 95% CI, 0.2-0.4), and idiopathic thrombocytic purpura (IR = 0.15; 95% CI, 0.1-0.3). Among these conditions, 5 showed significant trends, with IRs increasing over time in pregnancy-related conditions (P < .001) and gynecological dysplasias (P = .02) while IRs decreased over time for encephalopathy (P < .001), pancreatitis (P = .002), and cardiac disorders (P = .007).
CONCLUSIONS: Between 2001 and 2006, the incidence for 3 conditions decreased and increased for 2 others, demonstrating the change in medical issues and conditions in perinatally infected youth. Continued surveillance with appropriate tools will be needed to assess the long-term effects of HAART and HIV as well as development of new noninfectious conditions of HIV.
Authors:
Sharon A Nachman; Miriam Chernoff; Philimon Gona; Russell B Van Dyke; Wayne M Dankner; George R Seage; James Oleske; Paige L Williams;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  163     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-02-19     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-71     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antiretroviral Therapy, Highly Active*
Child
Child, Preschool
Female
Genital Neoplasms, Female / complications
HIV Infections / complications*,  drug therapy,  transmission
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical*
Male
Pregnancy
Pregnancy Complications
Grant Support
ID/Acronym/Agency:
1U01 AI 068616/AI/NIAID NIH HHS; 5U01 AI 41110/AI/NIAID NIH HHS; M01 RR006192/RR/NCRR NIH HHS; M01 RR010710/RR/NCRR NIH HHS; M01 RR010710-070057/RR/NCRR NIH HHS; M01 RR010710-080057/RR/NCRR NIH HHS; M01 RR010710-095341/RR/NCRR NIH HHS; M01 RR010710-105855/RR/NCRR NIH HHS; U01 AI 068632/AI/NIAID NIH HHS; U01 AI068632-03/AI/NIAID NIH HHS
Investigator
Investigator/Affiliation:
Arlene Bardeguez / ; Arry Dieudonne / ; Linda Bettica / ; Juliette Johnson / ; Stephen I Pelton / ; Ellen R Cooper / ; Lauren Kay / ; Ann Marie Regan / ; Joseph A Church / ; Theresa Dunaway / ; Audra Deveikis / ; Jagmohan Batra / ; Susan Marks / ; Ilaisanee Fineanganofo / ; Margaret A Keller / ; Nasser Redjal / ; Spring Wettgen / ; Sheryl Sullivan / ; Nancy Hutton / ; Beth Griffith / ; Mary Joyner / ; Carolyn Keifer / ; Douglas Watson / ; John Farley / ; Mary E Paul / ; Chivon D Jackson / ; Faith Minglana / ; Heidi Schwarzwald / ; Kenneth M Boyer / ; Jamie Martinez / ; James B McAuley / ; Maureen Haak / ; Michael Brady / ; Katalin Koranyi / ; Jane Hunkler / ; Charon Callaway / ; Gwendolyn B Scott / ; Charles D Mitchell / ; Claudia Florez / ; Joan Gamber / ; Diane W Wara / ; Ann Petru / ; Nicole Tilton / ; Mica Muscat / ; Ann Petru / ; Teresa Courville / ; Karen Gold / ; Katherine Eng / ; Stephen A Spector / ; Rolando M Viani / ; Mary Caffery / ; Kimberly Norris / ; Margaret Donnelly / ; Kathleen McGann / ; Carole Mathison / ; John Swetnam / ; Tom Belhorn / ; Jean Eddleman / ; Betsy Pitkin / ; Vincent R Bonagura / ; Susan Schuval / ; Blanka Kaplan / ; Constance Colter / ; Elaine J Abrams / ; Maxine Frere / ; Delia Calo / ; William Borkowsky / ; Nagamah Deygoo / ; Maryam Minter / ; Seham Akleh / ; Diana Dobbins / ; Deidre Wimbley / ; Lawrence D'Angelo / ; Hans Spiegel / ; Ann J Melvin / ; Kathleen M Mohan / ; Michele Acker / ; Suzanne Phelps / ; Kenneth C Rich / ; Karen Hayani / ; Julia Camacho / ; Warren A Andiman / ; Leslie Hurst / ; Janette de Jesus / ; Donna Schroeder / ; Denise Ferraro / ; Jane Perillo / ; Michele Kelly / ; Sohail Rana / ; Helga Finke / ; Patricia Yu / ; Jhoanna Roa / ; Andrea Kovacs / ; James Homans / ; Michael Neely / ; LaShonda Spencer / ; Mobeen H Rathore / ; Ayesha Mirza / ; Kathy Thoma / ; Almer Mendoza / ; Ana M Puga / ; Guillermo Talero / ; James Blood / ; Stefanie Juliano / ; Geoffrey A Weinberg / ; Barbra Murante / ; Susan Laverty / ; Francis Gigliotti / ; Suzanne R Lavoie / ; Tima Y Smith / ; Aditya Gaur / ; Katherine Knapp / ; Nehali Patel / ; Marion Donohoe / ; Irma L Febo / ; Licette Lugo / ; Ruth Santos / ; Ibet Heyer / ; Steven D Douglas / ; Richard M Rutstein / ; Carol A Vincent / ; Patricia C Coburn / ; Jill Foster / ; Janet Chen / ; Daniel Conway / ; Roberta Laguerre / ; Emma Stuard / ; Caroline Nubel / ; Stefan Hagmann / ; Murli Purswani / ; Mahrukh Bamji / ; Indu Pathak / ; Savita Manwani / ; Ekta Patel / ; Katherine Luzuriaga / ; Richard Moriarty / ; Barbara W Stechenberg / ; Donna J Fisher / ; Alicia M Johnston / ; Maripat Toye / ; Juan C Salazar / ; Kirsten Fullerton / ; Gail Karas / ; Stuart Foshee / ; Chitra S Mani / ; Dennis L Murray / ; Christopher White / ; Mary Y Mancao / ; Benjamin Estrada / ; Ronald D Wilcox / ; Margarita Silio / ; Thomas Alchediak / ; Cheryl Borne / ; Shelia Bradford /
Comments/Corrections
Erratum In:
Arch Pediatr Adolesc Med. 2009 Apr;163(4):364

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