| Incidence of new fractures in women with osteoporosis-induced vertebral fractures detected on routine lateral chest radiographs. | |
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MedLine Citation:
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PMID: 20577909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Vertebral fractures represent one of the major complications of osteopororis. Diagnosis is followed by a pharmacological, interventional or surgical treatment. Up to day there are non practice guidelines for a screening evaluation of bone fractures in elderly and most of the fractures remain undiagnosed. We prospectively evaluated the prevalence of vertebral fractures on chest X-rays to determine the diagnostic and prognostic roles of chest X-ray in predicting new bone fractures 2 years after the initial radiogram. MATERIALS AND METHODS: Between March 2004 and October 2005, 4,045 women underwent chest X-ray in our radiology department for any indication. We identified 166 women with the presence of at least one vertebral fracture. A questionnaire was administered to these women to collect information about diagnosis of osteoporosis, history of malignancy, systemic diseases, osteoporosis-inducing drugs and pharmacological, radiological or surgical treatment received. RESULTS: Out of the 166 women (age 73+/-10.5 years) with vertebral fractures, we interviewed 101 women; 13 had died and 52 were not found. Most of the patients were on menopause (97.1%, 98/101) with an average age of menopause of 48,2 years (+/-6 years). Among the patients on menopause, 15,8% (16/101) had undergone hysterectomy. All patients received a diagnosis of osteoporosis, which was reached with a chest X-ray report in 23.7% (24/101) of cases. A new skeletal fracture occurred in 20.5% (5/27) of patients receiving treatment against a frequency of 20.8% (16/74) in patients without treatment. No statistical difference was found between the groups (p = 0.374). CONCLUSIONS: Inadequate treatment may explain the lack of a substantial difference in new fracture risk between treated and untreated patients. For these reason we discuss about the evaluation of an adeguate therapeutic approaches in prevention of osteoporosis-induced fractures. |
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Authors:
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F Occhicone; C C Quattrocchi; N Napoli; P Dell'Aia; F D'Agostino; P Pozzilli; B Beomonte Zobel |
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Publication Detail:
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Type: Journal Article Date: 2010-06-24 |
Journal Detail:
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Title: La Radiologia medica Volume: 115 ISSN: 1826-6983 ISO Abbreviation: Radiol Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177625 Medline TA: Radiol Med Country: Italy |
Other Details:
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Languages: eng; ita Pagination: 815-25 Citation Subset: IM |
Affiliation:
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Department of Radiology, Interdisciplinary Center for Biomedical Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy. f.occhicone@unicampus.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chi-Square Distribution Female Fractures, Bone / epidemiology, etiology*, radiography* Humans Hysterectomy / statistics & numerical data Incidence Osteoporosis / complications*, epidemiology, radiography* Prognosis Questionnaires Radiography, Thoracic* Spinal Fractures / epidemiology, etiology*, radiography* |
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