| Incidence of neurological complications in patients with native-valve infective endocarditis and cerebral microembolism: an open cohort study. | |
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MedLine Citation:
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PMID: 19685379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this open cohort study was to assess the association between neurological complications in patients with definite native-valve infective endocarditis (IE) and cerebral microembolism (MES). MES detection was performed with 1-h, bilateral middle cerebral arteries (MCA) insonation using a transcranial Doppler ultrasound (TCD) machine. Thirty patients with definite native-valve IE were stratified into 2 groups based upon the presence of MES. The most striking difference between the 2 groups of patients was the incidence of clinically evident neurological complications. Neurological complications of IE occurred in 10 (83.3%) patients with positive MES and in 6 (33.3%) MES-negative patients (p=0.021). Ischaemic stroke was the most common complication, occurring in 11 of 16 patients, followed by meningitis in 4 patients and cerebritis in 1 patient. There was a trend towards greater in-hospital mortality in patients with recorded MES than in the MES-negative, although this was not statistically significant (33.3% vs 16.6%; p=0.392). Our results reveal a significant association between MES and neurological complications in patients with native-valve IE. TCD is a promising tool in predicting individual patient risk for neurological complications of IE. |
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Authors:
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Dragan Lepur; Bruno Barsi? |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 41 ISSN: 1651-1980 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: England |
Other Details:
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Languages: eng Pagination: 708-13 Citation Subset: IM |
Affiliation:
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Department of Neuroinfections and Intensive Care Medicine, University Hospital for Infectious Diseases Dr. Fran Mihaljevi?, Zagreb, Croatia. lepurix@inet.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Abscess / etiology, ultrasonography Brain Ischemia / etiology, ultrasonography Cerebral Hemorrhage / etiology, ultrasonography Chi-Square Distribution Cohort Studies Endocarditis / complications*, ultrasonography Female Humans Intracranial Embolism / complications*, ultrasonography Male Meningitis / etiology, ultrasonography Middle Aged Nervous System Diseases / etiology*, ultrasonography Prospective Studies Ultrasonography, Doppler, Transcranial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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