| Incidence and mortality of primary sclerosing cholangitis in the UK: a population-based cohort study. | |
| | |
MedLine Citation:
|
PMID: 18433916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: Little is known about the occurrence of Primary Sclerosing Cholangitis (PSC) in the population of the United Kingdom or its associated risks of mortality and malignancy. We aimed to fill these gaps in knowledge. METHODS: We identified 223 people with PSC and 2217 control subjects from the General Practice Research Database in the UK. We calculated incidence rates (1991-2001) and mortality rates and used Poisson and Cox regression to make comparisons between populations. RESULTS: There were 149 incident cases giving a rate of 0.41 per 100,000 person years (95% CI 0.34-0.48) and a prevalence in 2001 of 3.85 per 100,000 (95% CI 3.04 to 4.80). The incidence of PSC increased about 50% over the period studied and was higher in men compared with women. There was a three-fold mortality rate increase (Hazard ratio 2.92 (95% CI 2.16-3.94) in people with PSC compared to the general population, a two-fold increase in risk of any malignancy and a 40-fold increase in the risk of primary liver cancer (HR 2.23 and 37.44, respectively). CONCLUSIONS: We believe this paper provides the most reliable estimates of the occurrence of PSC and of its risk in terms of death and malignancy in the UK available to date. |
| | |
Authors:
|
Tim R Card; Masoud Solaymani-Dodaran; Joe West |
Related Documents
:
|
19038836 - Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival... 8144286 - Gender differential in all-cause and cardiovascular disease mortality. 15026446 - Effects of education and other socioeconomic factors on middle age mortality in rural b... 19264846 - Non-response to baseline, non-response to follow-up and mortality in the whitehall ii c... 22294826 - Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women. 16053646 - Falls among elderly persons in latin america and the caribbean and among elderly mexica... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-31 |
Journal Detail:
|
Title: Journal of hepatology Volume: 48 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-12 Completed Date: 2008-09-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
|
Languages: eng Pagination: 939-44 Citation Subset: IM |
Affiliation:
|
University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK. tim.card@nottingham.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Cholangitis, Sclerosing / mortality* Cohort Studies Female Great Britain / epidemiology Humans Incidence Infant Infant, Newborn Kaplan-Meiers Estimate Male Middle Aged Proportional Hazards Models |
| Grant Support | |
ID/Acronym/Agency:
|
//Department of Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leisure time physical activity in individuals with screen-detected type 2 diabetes compared to those...
Next Document: Allogeneic hematopoietic cell transplant in HCV-infected patients.