| Incidence of low free T4 values in premature infants as determined by direct equilibrium dialysis. | |
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MedLine Citation:
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PMID: 15306825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The incidence of transient reductions in serum free T(4) (FT(4)) in premature infants may be overestimated because certain FT(4) analytical methods underestimate FT(4) concentrations. Transient reductions of FT(4) measurements have been reported in the majority of premature newborn infants. Direct equilibrium dialysis (DED) does not underestimate FT(4) concentrations and is the best available technique to measure serum FT(4) in the premature infant. OBJECTIVE: To evaluate the incidence of low FT(4) concentrations in premature infants using DED to measure FT(4). DESIGN/METHOD: We measured FT(4) by DED in infants with birth weight <1500 g. Infants were excluded if the following conditions were present: congenital anomalies or maternal thyroid disorders. Free T(4) was measured at 14 days of life. Low FT(4) was defined using a statistical definition of FT(4) measurements <10.3 pmol/l (0.8 ng/dl). RESULTS: Free T(4) was measured by DED in 114 infants. Low FT(4) levels were seen in nine infants (7.9%). CONCLUSION: The incidence of low FT(4) was much lower than previously reported when FT(4) was measured using DED indicating that methodological issues are involved in the variability among estimates of the frequency of transient reduction in FT(4). |
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Authors:
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Christopher W Rabin; Andrew O Hopper; Leela Job; Ricardo L Peverini; Susan J Clark; Douglas D Deming; Jerald C Nelson; Nidia R Vyhmeister |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 24 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-29 Completed Date: 2004-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 640-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Coleman Pavilion Room 11121C, Loma Linda University School of Medicine, 11175 Campus Street, Coleman Pavilion, Suite 11121, Loma Linda, CA 92354, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Female Follow-Up Studies Gestational Age Humans Hypothyroidism / diagnosis*, epidemiology* Incidence Infant, Newborn Infant, Premature* Intensive Care Units, Neonatal Male Pregnancy Probability Radioimmunoassay Risk Assessment Sensitivity and Specificity Statistics, Nonparametric Thyroid Function Tests Thyroxine / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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