Document Detail


Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage.
MedLine Citation:
PMID:  18596706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: As Ureaplasmas may be pathogens in preterm infants, this study was conducted to determine the incidence of invasive disease with Ureaplasma parvum and Ureaplasma urealyticum and the relationship with adverse outcomes in a prospective cohort of very low birth weight (VLBW) infants. STUDY DESIGN: DNA was extracted from the cord or venous blood and cerebrospinal fluid (CSF) samples obtained from 313 VLBW infants. PCR was performed using primers for the mba gene to detect all 14 serovars and then repeated for all positive samples using species-specific primers. RESULT: Ureaplasma species were detected in serum and/or CSF samples from 74 of 313 (23.6%) infants. U. parvum was the predominant species (70%). Presence of Ureaplasma was significantly associated with elevated interleukin-1beta in cord blood (odds ratio (OR) 2.6, 1.05 to 6.45, P=0.039). Ureaplasma serum-positive infants had a 2.3-fold increased risk of intraventicular hemorrhage > or =grade 3 (OR 2.50; 1.06 to 5.89, P=0.036). CONCLUSION: Invasive Ureaplasma occurs commonly in VLBW infants and may increase the risk for severe intraventricular hemorrhage.
Authors:
R M Viscardi; N Hashmi; G W Gross; C-C J Sun; A Rodriguez; K D Fairchild
Related Documents :
17077266 - Acog committee opinion no. 348, november 2006: umbilical cord blood gas and acid-base a...
20568956 - Umbilical cord blood cd45(+)cd34(+) cells coexpression in preterm and full-term neonate...
7460466 - Congenital syphilis. a study of physical and biochemical aspects.
3501346 - Interleukin-1 activity from human cord blood monocytes.
19527476 - 2008 emily cooley memorial lecture: lessons learned from pediatric transfusion medicine...
8447946 - Limiting effects of uterine crowding on the number and weight of live pups at birth in ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-03
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-65     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. rviscard@umaryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bacteremia / complications*,  microbiology
Bronchopulmonary Dysplasia / microbiology
Cerebral Hemorrhage / complications,  microbiology*
Cerebrospinal Fluid / microbiology*
Female
Fetal Blood / microbiology
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / microbiology
Infant, Very Low Birth Weight
Placenta / microbiology,  pathology
Prospective Studies
Ureaplasma / isolation & purification
Ureaplasma Infections / complications*
Grant Support
ID/Acronym/Agency:
R01 HL71113/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome.
Next Document:  Using umbilical cord tissue to detect fetal exposure to illicit drugs: a multicentered study in Utah...