Document Detail

Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage.
MedLine Citation:
PMID:  18596706     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: As Ureaplasmas may be pathogens in preterm infants, this study was conducted to determine the incidence of invasive disease with Ureaplasma parvum and Ureaplasma urealyticum and the relationship with adverse outcomes in a prospective cohort of very low birth weight (VLBW) infants. STUDY DESIGN: DNA was extracted from the cord or venous blood and cerebrospinal fluid (CSF) samples obtained from 313 VLBW infants. PCR was performed using primers for the mba gene to detect all 14 serovars and then repeated for all positive samples using species-specific primers. RESULT: Ureaplasma species were detected in serum and/or CSF samples from 74 of 313 (23.6%) infants. U. parvum was the predominant species (70%). Presence of Ureaplasma was significantly associated with elevated interleukin-1beta in cord blood (odds ratio (OR) 2.6, 1.05 to 6.45, P=0.039). Ureaplasma serum-positive infants had a 2.3-fold increased risk of intraventicular hemorrhage > or =grade 3 (OR 2.50; 1.06 to 5.89, P=0.036). CONCLUSION: Invasive Ureaplasma occurs commonly in VLBW infants and may increase the risk for severe intraventricular hemorrhage.
R M Viscardi; N Hashmi; G W Gross; C-C J Sun; A Rodriguez; K D Fairchild
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-03
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-65     Citation Subset:  IM    
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Bacteremia / complications*,  microbiology
Bronchopulmonary Dysplasia / microbiology
Cerebral Hemorrhage / complications,  microbiology*
Cerebrospinal Fluid / microbiology*
Fetal Blood / microbiology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / microbiology
Infant, Very Low Birth Weight
Placenta / microbiology,  pathology
Prospective Studies
Ureaplasma / isolation & purification
Ureaplasma Infections / complications*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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