| Incidence of intratubular germ cell neoplasia in androgen insensitivity syndrome. | |
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MedLine Citation:
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PMID: 2173324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gonadal histology was investigated by means of conventional microscopy in 6 patients with complete androgen insensitivity syndrome, in 11 with incomplete androgen insensitivity syndrome, and in 3 with 5 alpha-reductase syndrome. Twelve subjects were prepubertal and 8 pubertal. In all patients gonadal tissue was removed as a prophylactic measure and no patients gave rise to any clinical suspicion of a tumour. Eight patients with incomplete androgen insensitivity syndrome, 5 of whom (62.5%) were prepubertal, showed intratubular germ cell neoplasia and in 6 of them it was bilateral. Histochemical and immunohistochemical analysis showed considerable agreement between atypical morphological aspects and positive response to Schiff's periodic acid and to staining with the anti-placenta alkaline phosphatase antibody. Our patients were characterized by one of the highest reported incidences of intratubular germ cell neoplasia, particularly at prepubertal age. These findings would seem to indicate that a rethink is needed concerning the general opinion that patients with androgen intensivity syndrome have practically no risk of developing malignancy, and that orchidectomy is not advisable before puberty is completed. |
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Authors:
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A Cassio; E Cacciari; A D'Errico; A Balsamo; F W Grigioni; M G Pascucci; F Bacci; M Tacconi; A M Mancini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 123 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-12-27 Completed Date: 1990-12-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 416-22 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Androgens / physiology* Child Child, Preschool Chorionic Gonadotropin / diagnostic use Dihydrotestosterone / blood Humans Infant Leydig Cells / pathology Male Neoplasms, Germ Cell and Embryonal / complications*, pathology Pseudohermaphroditism / blood, complications*, pathology Seminiferous Tubules / pathology Sertoli Cells / pathology Syndrome Testicular Neoplasms / complications*, pathology Testosterone / blood Testosterone 5-alpha-Reductase / deficiency |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Chorionic Gonadotropin; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; EC 1.3.99.5/Testosterone 5-alpha-Reductase |
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