Document Detail

Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009.
MedLine Citation:
PMID:  23210456     Owner:  NLM     Status:  Publisher    
Please cite this paper as: Azziz-Baumgartner et al. (2012) Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12022. Background  We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness. Methods  We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥65 years, we used Poisson regression of the influenza-associated rates. Results  During 2002-2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100 000 person-years (95% CI 4-8/100 000 person-years for P&I and 21/100 000 person-years (95% CI 12-31/100 000 person-years) for R&C. During 2005-2008, we identified an average of 7868 P&I excess hospitalizations and 22 994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10 000 person-years (95% CI 1-3/10 000 person-years) for P&I and 6/10 000 person-years (95% CI 3-8/10 000 person-years) for R&C. Conclusion  Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.
Eduardo Azziz-Baumgartner; Ana María Cabrera; Po-Yung Cheng; Enio Garcia; Gabriela Kusznierz; Rogelio Calli; Clarisa Baez; María Pía Buyayisqui; Eleonora Poyard; Emanuel Pérez; Ricardo Basurto-Davila; Rakhee Palekar; Otavio Oliva; Airlane Pereira Alencar; Regilo de Souza; Thais Dos Santos; David K Shay; Marc-Alain Widdowson; Joseph Breese; Horacio Echenique
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  Influenza and other respiratory viruses     Volume:  -     ISSN:  1750-2659     ISO Abbreviation:  Influenza Other Respi Viruses     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101304007     Medline TA:  Influenza Other Respi Viruses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published 2012. This article is a US Government work and is in the public domain in the USA.
Influenza Division, U.S. Centers for Disease Control and Prevention, USA. Dirección de Epidemiología, Ministerio de Salud de la Nación, Argentina. Instituto Nacional de Enfermedades Respiratorias 'Dr. Emilio Coni,' Argentina. Dirección de Epidemiología, Ministerio de Salud Pública Provincia de Tucumán, Argentina. Pan American Health Organization. Institute of Mathematics and Statistics - University of São Paulo, Brazil. Ministerio de Salud de la Provincia de Buenos Aires, Buenos Aires, Argentina.
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