Document Detail

Incidence of inflammatory bowel disease is rising and abdominal tuberculosis is falling in Bangladeshis in East London, United Kingdom.
MedLine Citation:
PMID:  15330914     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Ulcerative colitis (UC) and Crohn's disease (CD) were previously thought to be uncommon and abdominal tuberculosis (TB) common in patients from Bangladesh. We have reevaluated their incidence in Bangladeshis resident in East London. METHODS: Bangladeshis resident in Tower Hamlets presenting between 1997 and 2001 were identified from pathology, endoscopy, and medical records. Demographic, clinical, and management details were recorded. Incidences were calculated and compared with those from 1981 to 1989. RESULTS: Sixteen Bangladeshi patients with UC, 19 with CD, and 5 with abdominal TB were identified. Between 1997 and 2001, the age-standardized incidence of UC was 8.2/10(5)/yr (95% CI 2.5-13.9) compared with 2.4 (95% CI 0.8-3.8) in 1981-1989, and that of CD was 7.3/10(5)/yr (95% CI 2.0-12.6) (2.3, 95% CI 0.7-3.7 in 1981-1989). The standardized ratios for the incidences of UC and CD in recent periods compared with previous periods were 2.1 (95% CI 0.9-3.9) and 2.5 (1.2-4.6), respectively. There was a significant increase in the number of Bangladeshis developing CD by age <20 yr between the earlier and more recent periods (p < 0.02). The standardized incidence of abdominal TB was 2.5/10(5)/yr (95% CI 0.2-4.8) in 1997-2001, and 7.4 (95% CI 2.1-12.7) in 1985-1989 (p < 0.05). The standardized ratio for the incidence of TB in the two periods was 0.22 (95% CI 0.07-0.53). CONCLUSIONS: In Bangladeshis in East London, the incidence of IBD has increased and of abdominal TB has fallen over the last decade; CD has become a more likely diagnosis than abdominal TB. Clinicians in the Western world need to be aware of the changing incidences of IBD and abdominal TB in South Asians.
Eftychia Tsironi; Roger M Feakins; Chris S J Probert; Chris S J Roberts; David S Rampton; D Phil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  99     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-27     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1749-55     Citation Subset:  IM    
Academic Departments of Adult and Paediatric Gastroenterology and of Histopathology, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK.
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MeSH Terms
Age Distribution
Aged, 80 and over
Bangladesh / ethnology
Child, Preschool
Cohort Studies
Colitis, Ulcerative / diagnosis,  epidemiology*
Confidence Intervals
Crohn Disease / diagnosis,  epidemiology*
Emigration and Immigration*
Great Britain / epidemiology
Inflammatory Bowel Diseases / diagnosis,  epidemiology
Middle Aged
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Rate
Tuberculosis, Gastrointestinal / diagnosis*,  epidemiology*
Erratum In:
Am J Gastroenterol. 2005 Jan;100(1):255
Note: Roberts, Chris SJ [corrected to Probert, Chris SJ]

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