| Incidence of hepatic dysfunction is equivalent in burn patients receiving oxandrolone and controls. | |
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MedLine Citation:
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PMID: 17438485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxandrolone has been shown to improve lean muscle mass in patients with burns. Hepatic dysfunction is a known side effect of treatment with oxandrolone. The purpose of this study was to examine the incidence of hepatic dysfunction in our series of burn patients receiving oxandrolone. Fourteen patients who received oxandrolone (5 mg, n = 8; 10 mg, n = 6) were identified from our prospectively collected burn database. The records of 61 control patients also were reviewed. Demographics such as age, comorbidities, and burn size were recorded. The incidence of hepatic dysfunction was determined by the presence of abnormal liver function tests. The study and control groups were similar in age and burn size. Two of the eight (25%) oxandrolone patients receiving 5 mg and four of the six (67%) oxandrolone patients receiving 10 mg had evidence of hepatic dysfunction. Twenty six of the 61 (43%) control patients had evidence of hepatic dysfunction (P = NS). There appears no significant increased incidence of hepatic dysfunction in burn patients who received oxandrolone compared to those who did not. |
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Authors:
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Mona C McCullough; Nicholas Namias; Carl Schulman; Ellie Gomez; Ron Manning; Seth Goldberg; Louis Pizano; Gillon C Ward |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of burn care & research : official publication of the American Burn Association Volume: 28 ISSN: 1559-047X ISO Abbreviation: - Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-08-10 Completed Date: 2007-10-15 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101262774 Medline TA: J Burn Care Res Country: United States |
Other Details:
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Languages: eng Pagination: 412-20 Citation Subset: IM |
Affiliation:
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University ofMiami-Miller School ofMedicine, DeWitt Daughtry Family Department of Surgery, Division of Burns, Miami, Florida, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / drug effects Anabolic Agents / adverse effects*, therapeutic use Androgens / adverse effects*, therapeutic use Aspartate Aminotransferases / drug effects Body Composition / drug effects* Burns / drug therapy* Case-Control Studies Drug-Induced Liver Injury* Female Humans Incidence Liver / drug effects* Male Middle Aged Oxandrolone / adverse effects*, therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 53-39-4/Oxandrolone; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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