| Incidence of hand eczema in a population-based twin cohort: genetic and environmental risk factors. | |
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MedLine Citation:
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PMID: 17635505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Population-based studies on the incidence of hand eczema are sparse. OBJECTIVES: The aim of this prospective follow-up study was to determine the incidence rate of hand eczema in a population-based twin cohort. Secondly, the role of genetic factors and other potential risk factors for hand eczema was investigated. METHODS: A questionnaire on self-reported hand eczema was answered by 5610 and 4128 twin individuals in 1996 and 2005, respectively. Data were analysed in a Poisson regression analysis. RESULTS: The crude incidence rate was 8.8 cases per 1000 person-years (95% confidence interval, [CI] 7.7-9.9). Incidence rate ratios (IRRs) dependent on the co-twin's hand eczema status revealed a significant, doubled risk for monozygotic twin individuals with a co-twin affected by hand eczema, compared with dizygotic twin individuals with a co-twin affected by hand eczema (IRR 2.4, 95% CI 1.4-4.1). Also, significantly increased IRRs were found for positive patch test, atopic dermatitis, and wet work. CONCLUSIONS: Hand eczema is still a frequent disease and genetic factors are confirmed important risk factors. Positive patch test, atopic dermatitis and wet work were associated with an increased risk, whereas no association with age, sex, smoking or alcohol was found. |
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Authors:
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A Lerbaek; K O Kyvik; H Ravn; T Menné; T Agner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2007-07-16 |
Journal Detail:
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Title: The British journal of dermatology Volume: 157 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 552-7 Citation Subset: IM |
Affiliation:
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National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark. anne.lerbaek@dadlnwt.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Denmark / epidemiology Dermatitis, Contact / epidemiology* Epidemiologic Methods Female Hand Dermatoses / epidemiology* Humans Male Middle Aged Sex Distribution Twins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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