Document Detail

Incidence of factor V Leiden in patients with acute myocardial infarction.
MedLine Citation:
PMID:  10590188     Owner:  NLM     Status:  MEDLINE    
The genetic defect of coagulation factor V known as factor V Leiden produces a resistance to degradation by activated protein C (APC) and increases the risk of venous thromboembolism. The data on arterial thrombosis associated with APC resistance are still not clearly defined. We conducted a study in patients presenting with acute myocardial infarction (MI) to assess whether factor V Leiden increases the risk of arterial thrombosis. We studied 109 patients who had a diagnosis of acute MI (69 males and 40 females, aged 25-91 years), and 112 controls. The study population was identified by characteristic ECG changes and elevation of serum CK-MB, whereas the control subjects were anonymous healthy blood donors with no known history of coronary artery disease. Blood samples from the patients and controls were analyzed for the factor V Leiden mutation by DNA analysis, using the polymerase chain reaction. Heterozygous factor V Leiden mutation was found in 9 of 109 (8%) MI patients and 5 of 112 (4%) control subjects (P =.42). In conclusion, this study shows no evidence of an association between factor V Leiden and acute MI.
M S Gowda; M L Zucker; J L Vacek; W L Carriger; D L Van Laeys; J M Rachel; B D Strope
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  9     ISSN:  0929-5305     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-01     Completed Date:  2000-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  IM    
University of MissouriKansas City, Mid America Heart Institute and Department of Pathology, St. Lukes Hospital, Kansas City, Missouri, USA.
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MeSH Terms
Activated Protein C Resistance
Aged, 80 and over
Cohort Studies
Factor V / genetics*
Middle Aged
Myocardial Infarction / blood,  etiology,  genetics*
Point Mutation
Polymerase Chain Reaction
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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