Document Detail


Incidence of factor FVIIIC deficiency in live male infants undergoing circumcision in South West, Nigeria.
MedLine Citation:
PMID:  17880445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prominent evidence of inherited bleeding disorder in newborn males is excessive post-circumcision bleeding. Male circumcision in Nigeria is the rule rather than the exception. Male siblings of some of the Nigerian haemophiliacs consequently died from severe post-circumcision bleeding. The aim was to determine the incidence of inherited factor VIIIc (FVIIIc) deficiencies in live male infants undergoing circumcision in South West, Nigeria. The study population was 244 male infants drawn from University College Hospital and Our Lady of Apostles Catholic Hospital, Oluyoro, Ibadan. Pre-circumcision prothrombin time, activated partial thromboplastin time and FVIIIc levels were determined. Clinical features of inherited bleeding disorder particularly family history of bleeding diathesis, history of cephalhaematoma and bleeding from the umbilical stump in neonatal life were determined with the aid of a questionnaire. Only one of the mothers (0.4%) gave a family history of bleeding disorder. A history of excessive bleeding from the umbilical stump post delivery was obtained in three (2%) of the patients. Five (2%) other subjects had cephalhaematoma post delivery. Two of the subjects (0.8%) had prolonged activated partial thromboplastin time. The factor VIIIc level was between 31% and 49% in 16.1%, while 1.6% of the neonates had levels between 20% and 26%. This study detected four of the 244 (1.64%) neonates with FVIIIc deficiency, suggestive of either mild haemophilia or von Willebrand's disease. A larger study (including family studies) will be required, so as to arrive at the exact incidence of both haemophilia A and vWD in live male infants in Nigeria.
Authors:
E E Fakunle; W A Shokunbi; O B Shittu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  13     ISSN:  1351-8216     ISO Abbreviation:  Haemophilia     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-12-07     Revised Date:  2009-10-21    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-9     Citation Subset:  IM    
Affiliation:
Department of Haematology, University College Hospital, Ibadan, Oyo State, Nigeria.
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MeSH Terms
Descriptor/Qualifier:
Circumcision, Male / statistics & numerical data*
Follow-Up Studies
Hemophilia A / epidemiology*
Hemorrhage / epidemiology
Humans
Incidence
Infant
Male
Nigeria / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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