Document Detail

Incidence and determinants of moderate COPD (GOLD II) in male smokers aged 40-65 years: 5-year follow up.
MedLine Citation:
PMID:  16953996     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major health problem with an estimated prevalence of 10-15% among smokers. The incidence of moderate COPD, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), is largely unknown.
AIM: To determine the cumulative incidence of moderate COPD (forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC] <0.7 and FEV1 <80% predicted) and its association with patient characteristics in a cohort of male smokers.
DESIGN: Prospective cohort study.
SETTING: The city of IJsselstein, a small town in the Netherlands.
METHOD: Smokers aged 40-65 years who were registered with local GPs, participated in a study to identify undetected COPD. Baseline measurements were taken in 1998 of 399 smokers with normal spirometry (n = 292) or mild COPD (FEV1/FVC <0.7 and FEV1 >or=80% predicted, n = 107) and follow-up measurements were conducted in 2003.
RESULTS: After a mean follow-up of 5.2 years, 33 participants developed moderate COPD (GOLD II). This showed an estimated cumulative incidence of 8.3% (95% CI = 5.8 to 11.4) and a mean annual incidence of 1.6%. No participant developed severe airflow obstruction. The risk of developing moderate COPD in smokers with baseline mild COPD (GOLD I) was five times higher than in those with baseline normal spirometry (one in five versus one in 25).
CONCLUSIONS: In a cohort of middle-aged male smokers, the estimated cumulative incidence of moderate COPD (GOLD II) over 5 years was relatively high (8.3%). Age, childhood smoking, cough, and one or more GP contacts for lower respiratory tract problems were independently associated with incident moderate COPD.
Roeland M M Geijer; Alfred P E Sachs; Theo J M Verheij; Philippe L Salomé; Jan-Willem J Lammers; Arno W Hoes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of general practice : the journal of the Royal College of General Practitioners     Volume:  56     ISSN:  0960-1643     ISO Abbreviation:  Br J Gen Pract     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2007-04-06     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  9005323     Medline TA:  Br J Gen Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  656-61     Citation Subset:  IM    
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, the Netherlands.
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MeSH Terms
Cohort Studies
Follow-Up Studies
Forced Expiratory Volume
Middle Aged
Multivariate Analysis
Netherlands / epidemiology
Prospective Studies
Pulmonary Disease, Chronic Obstructive / epidemiology*,  etiology
Severity of Illness Index
Smoking / adverse effects*,  epidemiology
Spirometry / methods
Time Factors
Vital Capacity
Comment In:
Br J Gen Pract. 2006 Nov;56(532):883   [PMID:  17132358 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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