Document Detail

Incidence of cutaneous vasoactivity in patients with anemia and pulmonary hypoxia.
MedLine Citation:
PMID:  10901088     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In cutaneous laser Doppler flow (LDF)-recordings, various forms of flowmotion or vasoactivity can be observed. It is still a matter of dispute, whether flowmotion is a phenomenon of physiological or pathophysiological conditions. Therefore, we tested the hypothesis of increased vasoactivity being typical for patients with various degrees of acute and chronic anemia as well as with chronic obstructive pulmonary disease (COPD).
PATIENTS AND METHODS: We examined 12 healthy controls, 14 patients with COPD with a PO2 below 60 mmHg, 16 patients with chronic and 7 patients with acute anemia with an Hb below 12 g/dl. We used a simple LDF-technique on the dorsum of the forefoot. The regularity of blood flow frequencies was determined by calculation of the coefficient of variation.
RESULTS: Periods without vasoactivity (i.e. constant flow pattern) were 21% in normal controls, 7% in patients with COPD and 2% in patients with acute or chronic anemia. Mean frequencies in the four groups varied between 3.8 and 4.8 cpm, with significant changes only in the group with acute blood loss. However, vasoactivity was significantly more regular in the COPD- and anemia-groups as compared to normal controls, with coefficients of variation of 47.4% for controls, 31.8% for COPD- and 29.3% for chronic and 35.1% for acute anemia-patients.
CONCLUSIONS: The present paper shows that cutaneous vasoactivity is more regular in the three examined clinical entities of systemic tissue hypo-oxygenation, i.e. chronic and acute anemia and severe COPD as compared to healthy control subjects. Therefore, we hypothesize that increased vasoactivity constitutes a regulatory defense mechanism in cases of reduced oxygenation, by improving microcirculatory blood flow distribution.
C Schmidt-Lucke; G Glattkowski-Schäfer; C Kirchhof; A von Bierbrauer; H U Klein; J A Schmidt-Lucke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  29     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-26     Completed Date:  2000-09-26     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  IM    
Medizinische Universitätskliniken Magdeburg, Germany.
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MeSH Terms
Anemia / physiopathology*
Anoxia / physiopathology*
Laser-Doppler Flowmetry
Lung Diseases, Obstructive / physiopathology*
Middle Aged
Reference Values
Skin / blood supply*
Vascular Resistance / physiology*

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