Document Detail

Incidence, clinical spectrum, and outcome of intrauterine infections in neonates.
MedLine Citation:
PMID:  10893916     Owner:  NLM     Status:  MEDLINE    
A prospective study was undertaken on the incidence of intrauterine infections by screening 1302 cord blood samples for total IgM by radial immunodiffusion. Specific IgM against cytomegalovirus (CMV), rubella and Toxoplasma were estimated in cord blood samples found to contain total IgM > 20 mg/dl. All these neonates were examined at birth and at discharge. Cord blood samples with total IgM > 20 mg/dl were further screened for specific IgM against rubella, CMV and Toxoplasma. Neonates found to have positive specific IgM were followed-up for hearing, opthalmological and developmental assessment. Raised cord blood (IgM > 20 mg/dl) was found in 270/1302 (20.6 per cent). Mean birth weight was comparable in babies with raised (> 20 mg/dl) or low (< 20 mg/dl) cord blood total IgM. Incidence of prematurity and low birth weight were not statistically different in babies with raised cord blood IgM when compared to those with low cord blood IgM levels. Similarly, incidence of intrauterine growth retardation (IUGR) idiopathic was similar in two groups. Specific IgM for rubella was found to be positive in eight (0.6 per cent). Of these, three had symptomatic rubella infection. Two mothers of these symptomatic babies had exanthematous viral illness during first trimester. Specific IgM for CMV was found to be positive in 23 (1.8 per cent) while two infants had symptomatic CMV disease. None of the babies was found to have specific IgM against Toxoplasma. One baby with symptomatic CMV disease and one with rubella died. Another baby with symptomatic CMV disease developed neonatal hepatitis which improved on follow-up but the infant went on to develop sensorineural deafness. All other asymptomatic babies with specific IgM positive against rubella and CMV were found to have normal vision, hearing and development on follow-up.
A K Deorari; S Broor; R S Maitreyi; D Agarwal; H Kumar; V K Paul; M Singh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  46     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Pediatrics, Microbiology, All India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Cytomegalovirus / immunology
Cytomegalovirus Infections / blood,  diagnosis,  epidemiology
Fetal Blood / immunology*
Fetal Diseases / blood,  diagnosis,  epidemiology*
Immunoglobulin M / blood
Infant, Newborn
Prospective Studies
Rubella / blood,  diagnosis
Rubella virus / immunology
Sepsis / blood,  diagnosis,  epidemiology*
Toxoplasma / immunology
Toxoplasmosis / blood,  diagnosis,  epidemiology
Reg. No./Substance:
0/Immunoglobulin M

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