| Incidence and clinical significance of left ventricular thrombus in tako-tsubo cardiomyopathy assessed with echocardiography. | |
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MedLine Citation:
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PMID: 18334499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left ventricular (LV) thrombus is a known complication of tako-tsubo cardiomyopathy (TC). However, current literature almost exclusively consists of isolated case reports. The aim of this study was to determine the incidence and clinical significance of LV thrombus formation in TC. METHODS AND RESULTS: Over a 33-month period 52 patients with TC were assembled into a database at our institution. A retrospective database search was performed to identify patients with LV thrombus among these patients. LV thrombus, by echocardiography, was discovered in four patients[(8%); 95% confidence interval 3-19%]. Thrombus was present at the time of diagnosis in three patients. In one patient thrombus was absent initially and developed later. The LV apex was the site of thrombus formation in two patients, but the true apex was spared in the other two. All four patients had elevated serum levels of C-reactive protein (CRP). Two patients also had thrombocytosis. Treatment with low molecular weight heparin (LMWH) led to resolution of thrombus in all cases. CONCLUSION: Our findings suggest that LV thrombus is a noteworthy complication in TC. It can occur both at initial presentation or at anytime later during the disease course. Elevated CRP levels and thrombocytosis may indicate a higher risk of thrombus formation. |
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Authors:
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D Haghi; T Papavassiliu; F Heggemann; J J Kaden; M Borggrefe; T Suselbeck |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2008-03-10 |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 101 ISSN: 1460-2393 ISO Abbreviation: QJM Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-24 Completed Date: 2008-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
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Languages: eng Pagination: 381-6 Citation Subset: IM |
Affiliation:
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I. Medizinische Klinik, Universitätsklinikum Mannheim. 68167 Mannheim, Germany. dariush.haghi@med.ma.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / therapeutic use Echocardiography Female Heparin / therapeutic use Humans Retrospective Studies Takotsubo Cardiomyopathy / complications*, ultrasonography Thrombosis / complications*, ultrasonography Ventricular Dysfunction, Left / complications*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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