| Incidence and clinical manifestations of breast milk-acquired Cytomegalovirus infection in low birth weight infants. | |
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MedLine Citation:
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PMID: 15674408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the incidence and clinical manifestations of human breast milk (HMB)-associated acquired cytomegalovirus (CMV) infection in small premature infants. STUDY DESIGN: A prospective study of premature infants born at or prior to 32 weeks gestation, and or infants weighing 1500 g or less at birth. The babies were divided into two groups: Group 1 included babies of CMV seropositive mothers who received HBM throughout the study period. Group 2 included babies of seronegative mothers or babies that did not receive HBM at all. Urine sample were obtained once weekly from birth until the age of 8 weeks or until discharge and were tested for the presence of CMV-DNA by PCR. RESULTS: Four of 70 infants from group 1 (5.7%, 95% CI, 0 to 11%) acquired CMV infection between the ages of 3 and 7 weeks as compared to none of 26 babies in group 2. Only one infected baby had severe CMV disease with complete recovery. CONCLUSION: The relative incidence of HBM-associated CMV infection and the severity of HBM-associated CMV disease in premature infants are low. |
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Authors:
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Dan Miron; Sharon Brosilow; Klari Felszer; Dan Reich; David Halle; Daniel Wachtel; Arthur I Eidelman; Yechiel Schlesinger |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-29 Completed Date: 2005-08-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 299-303 Citation Subset: IM |
Affiliation:
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Pediatric Infectious Disease Consultation Service, Ha'Emek Medical Center, Afula, Rappaport School of Medicine, Haifa, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Feeding
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adverse effects Cohort Studies Confidence Intervals Cytomegalovirus Infections / diagnosis, epidemiology*, transmission* Female Follow-Up Studies Gestational Age Humans Incidence Infant, Newborn Infant, Premature* Infectious Disease Transmission, Vertical Israel / epidemiology Male Milk, Human / virology* Pregnancy Pregnancy Complications, Infectious / epidemiology* Probability Prospective Studies Risk Assessment |
| Comments/Corrections | |
Comment In:
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J Perinatol. 2005 May;25(5):297-8
[PMID:
15861195
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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