Document Detail

Incidence and clinical manifestations of breast milk-acquired Cytomegalovirus infection in low birth weight infants.
MedLine Citation:
PMID:  15674408     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the incidence and clinical manifestations of human breast milk (HMB)-associated acquired cytomegalovirus (CMV) infection in small premature infants. STUDY DESIGN: A prospective study of premature infants born at or prior to 32 weeks gestation, and or infants weighing 1500 g or less at birth. The babies were divided into two groups: Group 1 included babies of CMV seropositive mothers who received HBM throughout the study period. Group 2 included babies of seronegative mothers or babies that did not receive HBM at all. Urine sample were obtained once weekly from birth until the age of 8 weeks or until discharge and were tested for the presence of CMV-DNA by PCR. RESULTS: Four of 70 infants from group 1 (5.7%, 95% CI, 0 to 11%) acquired CMV infection between the ages of 3 and 7 weeks as compared to none of 26 babies in group 2. Only one infected baby had severe CMV disease with complete recovery. CONCLUSION: The relative incidence of HBM-associated CMV infection and the severity of HBM-associated CMV disease in premature infants are low.
Dan Miron; Sharon Brosilow; Klari Felszer; Dan Reich; David Halle; Daniel Wachtel; Arthur I Eidelman; Yechiel Schlesinger
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
Pediatric Infectious Disease Consultation Service, Ha'Emek Medical Center, Afula, Rappaport School of Medicine, Haifa, Israel.
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MeSH Terms
Breast Feeding / adverse effects
Cohort Studies
Confidence Intervals
Cytomegalovirus Infections / diagnosis,  epidemiology*,  transmission*
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Infectious Disease Transmission, Vertical
Israel / epidemiology
Milk, Human / virology*
Pregnancy Complications, Infectious / epidemiology*
Prospective Studies
Risk Assessment
Comment In:
J Perinatol. 2005 May;25(5):297-8   [PMID:  15861195 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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