| Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. | |
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MedLine Citation:
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PMID: 16840398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To assess the incidence of chronic thromboembolic pulmonary hypertension (CTPH) after the first episode of objectively confirmed pulmonary embolism (PE). DESIGN: Prospective cohort study in 12 Italian medical centers. PATIENTS: Consecutive patients treated with oral anticoagulants for the first episode of PE, either idiopathic or associated with temporary risk factors, were followed up for at least 3 years. Patients were excluded from the study if they had a known persistent risk factor for venous thromboembolism (VTE). INTERVENTIONS: At the follow-up visits, patients were evaluated for persistent dyspnea, either at rest or on exertion. All patients who were referred with dyspnea were assessed by transthoracic echocardiography, with evaluation of the systolic and mean pulmonary artery pressures. Patients with evidence of pulmonary hypertension on echocardiography underwent perfusion lung scans and pulmonary angiography to confirm the diagnosis of CTPH. RESULTS: Overall, 259 patients were included in the study. PE was idiopathic in 135 patients, while it was associated with at least a temporary risk factor for VTE in 124 patients. After an average follow-up period of 46 months, 37 patients were found to have persistent dyspnea that was unexplained in 5 patients. Among these patients, a diagnosis of CTPH was confirmed in two patients with idiopathic PE (0.8% of the overall study population [95% confidence interval (CI), 0.0 to 1.9]; 1.5% of patients with idiopathic PE [95% CI, 0.0 to 3.6]). The diagnosis was made 14 and 22 months, respectively, after the acute PE. CONCLUSIONS: The incidence of CTPH observed in this study was about 1%. CTPH was observed in two patients with idiopathic PE. |
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Authors:
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Cecilia Becattini; Giancarlo Agnelli; Raffaele Pesavento; Mauro Silingardi; Renzo Poggio; Maria Rita Taliani; Walter Ageno |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Chest Volume: 130 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-14 Completed Date: 2006-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 172-5 Citation Subset: AIM; IM |
Affiliation:
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Dipartimento di Medicina Interna, Medicina Interna e Cardiovascolare, Università di Perugia, Via G. Dottori, Ospedale Silvestrini, 06129 Perugia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / therapeutic use Confidence Intervals Dyspnea / etiology*, ultrasonography Female Follow-Up Studies Humans Hypertension, Pulmonary / epidemiology, etiology* Incidence Italy / epidemiology Male Pulmonary Embolism / complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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