Document Detail

Incidence of chronic pulmonary hypertension in patients with previous pulmonary embolism.
MedLine Citation:
PMID:  19193397     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The true incidence of chronic thromboembolic pulmonary hypertension (CTPH) remains a matter of debate. Symptomatic CTPH is probably more common than previously reported, whereas the occurrence of asymptomatic CTPH has not been defined since very limited evidence on the incidence of asymptomatic CTPH diagnosed with echocardiography Doppler are currently available. We therefore carried out a prospective cohort study to assess the incidence of CTPH diagnosed with echocardiography Doppler in consecutive patients with a first episode of PE. METHODS: Consecutive patients with a first episode of PE were evaluated with Doppler transthoracic echocardiography within 6 to 12 months after the index event. Pulmonary hypertension was defined as a systolic pulmonary artery pressure > or =40 mmHg at rest in the presence of residual perfusion defects at perfusion scintigraphy. Presence of symptoms related to pulmonary hypertension was evaluated with a standardized questionnaire. RESULTS: Ninety-one patients (mean age 61.9+/-15.7 years; range 22-89; 39 men) were enrolled. Eight patients (8.8%; 95% CI 4.5,16.4) had CTPH: of these, 4 (4.4%; 95% CI 2.0, 9.3) were symptomatic. CONCLUSIONS: Asymptomatic CTPH is not an uncommon finding after PE. Larger prospective trials with a longer follow up should assess the prognostic significance of asymptomatic CPTH.
Francesco Dentali; Marco Donadini; Monica Gianni; Andrea Bertolini; Alessandro Squizzato; Achille Venco; Walter Ageno
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Publication Detail:
Type:  Journal Article     Date:  2009-02-03
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-8     Citation Subset:  IM    
Department of Clinical Medicine, Insubria University, Varese, Italy.
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MeSH Terms
Aged, 80 and over
Chronic Disease
Hypertension, Pulmonary / diagnosis*,  epidemiology*
Italy / epidemiology
Middle Aged
Pulmonary Embolism / diagnosis*,  epidemiology*
Risk Assessment
Risk Factors

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