Document Detail

Incidence and causes of sepsis in glucose-6-phosphate dehydrogenase-deficient newborn infants.
MedLine Citation:
PMID:  2715888     Owner:  NLM     Status:  MEDLINE    
To determine the susceptibility to sepsis in newborn infants deficient in glucose-6-phosphate dehydrogenase (G6PD), we screened 33,943 Saudi Arab infants. Deficiency of G6PD was found in 18%. Sepsis was determined by the presence of clinical signs of sepsis and confirmed by positive blood cultures. Sepsis was documented in 75 infants (2.2/1000). The incidence of sepsis was significantly higher in 6138 G6PD-deficient infants (3.4/1000) than in the 27,805 with normal G6PD activity (1.9/1000; p less than 0.02). The incidence of catalase-positive organism sepsis was higher in G6PD-deficient infants (2.9/1000) compared with those with normal G6PD activity (1/1000; p less than 0.0002), whereas the incidence of catalase-negative organism sepsis did not differ (p less than 0.2). Deficiency of G6PD was more common in infants with late sepsis (46%) than in those with early sepsis (21%) and in all infants screened (18%) (p less than 0.03 and p less than 0.001, respectively). We conclude that neonates with G6PD deficiency are more susceptible to late sepsis and to infection with catalase-positive organisms. The exact mechanism for the increased susceptibility is not clear, but a partial explanation could be lack of leukocyte bactericidal activity associated with G6PD deficiency, and an increased susceptibility to infection caused by hyperferremia resulting from lysis of G6PD-deficient erythrocytes.
Y K Abu-Osba; A A Mallouh; R W Hann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  114     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-12     Completed Date:  1989-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  748-52     Citation Subset:  AIM; IM    
Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
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MeSH Terms
Bacteria / enzymology
Bacterial Infections
Disease Susceptibility
Glucosephosphate Dehydrogenase Deficiency / complications,  epidemiology*
Infant, Newborn
Risk Factors
Saudi Arabia
Sepsis / epidemiology*,  etiology
Reg. No./Substance:

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