Document Detail


Incidence of cardiovascular events after hospital admission for pneumonia.
MedLine Citation:
PMID:  21396508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Several studies have suggested an increased risk of cardiovascular events, primarily acute myocardial infarction, around the time of hospital admission for pneumonia. Therefore, we examined cardiovascular events, including myocardial infarction, congestive heart failure, unstable angina, stroke, and serious cardiac arrhythmias, within 90 days after hospitalization for pneumonia.
METHODS: By using data from the administrative databases of the Department of Veterans Affairs, we examined a cohort of subjects hospitalized with pneumonia between October 2001 and September 2007. Subjects were at least 65 years of age. We examined the incidence of myocardial infarction, congestive heart failure, cardiac arrhythmias, unstable angina, and stroke by International Classification of Diseases, Ninth Revision codes, excluding those with a diagnosis before the admission for pneumonia.
RESULTS: The cohort comprised 50,119 subjects with a mean age of 77.5 years (standard deviation 6.7 years), 98% of whom were male. The 90-day incidence of cardiovascular events was 1.5% for myocardial infarction, 10.2% for congestive heart failure, 9.5% for arrhythmia, 0.8% for unstable angina, and 0.2% for stroke. The majority of events occurred during the hospitalization for pneumonia.
CONCLUSION: A clinically important number of subjects in this cohort had a cardiovascular event within 90 days of hospital admission, suggesting that such events may have an important role in post-pneumonia mortality. Additional research is needed to determine whether interventions may reduce the number of cardiovascular events after pneumonia.
Authors:
Theodore W Perry; Mary Jo V Pugh; Grant W Waterer; Brandy Nakashima; Carlos J Orihuela; Laurel A Copeland; Marcos I Restrepo; Antonio Anzueto; Eric M Mortensen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  124     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-05-09     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  AIM; IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Angina, Unstable / epidemiology
Arrhythmias, Cardiac / epidemiology
Biological Markers / blood
Cardiovascular Diseases / blood,  epidemiology*,  etiology,  mortality
Cohort Studies
Comorbidity
Confounding Factors (Epidemiology)
Databases, Factual
Female
Heart Failure / epidemiology
Hospitalization*
Humans
Incidence
Inpatients / statistics & numerical data
Male
Myocardial Infarction / epidemiology
Odds Ratio
Pneumonia / blood,  complications*,  epidemiology*
Stroke / epidemiology
Time Factors
United States / epidemiology
United States Department of Veterans Affairs
Grant Support
ID/Acronym/Agency:
KL2 RR025766/RR/NCRR NIH HHS; KL2 TR000118/TR/NCATS NIH HHS; KL2RR025766/RR/NCRR NIH HHS; R01 NR010828/NR/NINR NIH HHS; R01 NR010828-03/NR/NINR NIH HHS; R01NR010828/NR/NINR NIH HHS; R21 HL108054/HL/NHLBI NIH HHS; R21 HL108054-01/HL/NHLBI NIH HHS; UL1 RR025767/RR/NCRR NIH HHS; UL1 TR000149/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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