| Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy. | |
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MedLine Citation:
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PMID: 15095214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective analysis sought to determine the comparative incidence of cross-reactivity associated with carbapenem antibiotic treatment among patients with versus those without penicillin allergy. We sought to determine whether the incidence of cross-reactivity is different between imipenem-cilastatin and meropenem. A total of 211 patients were treated with a carbapenem antibiotic. Included were 100 patients with and 111 patients without a documented or reported penicillin allergy. Within each group, subgroups of penicillin-allergic and penicillin-nonallergic patients were balanced equally between imipenem-cilastatin and meropenem. The incidence of patients with a reported or documented penicillin allergy experiencing an allergic-type reaction to a carbapenem was 11%, which is 5.2 times greater than the risk in patients who were reportedly not allergic to penicillin (P=.024). No difference in the occurrence of allergic-type reactions was observed between the 2 carbapenems. |
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Authors:
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William A Prescott; Daryl D DePestel; Jeffrey J Ellis; Randolph E Regal |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-03-26 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 38 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1102-7 Citation Subset: IM |
Affiliation:
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University of Michigan Health System, Department of Pharmacy Services, Ann Arbor, MI 48109-0008, USA. wprescot@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Carbapenems / adverse effects* Child Child, Preschool Drug Hypersensitivity / epidemiology, etiology* Female Humans Hypersensitivity / etiology Incidence Infant Male Middle Aged Penicillins / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Carbapenems; 0/Penicillins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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