Document Detail

Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy.
MedLine Citation:
PMID:  15095214     Owner:  NLM     Status:  MEDLINE    
This retrospective analysis sought to determine the comparative incidence of cross-reactivity associated with carbapenem antibiotic treatment among patients with versus those without penicillin allergy. We sought to determine whether the incidence of cross-reactivity is different between imipenem-cilastatin and meropenem. A total of 211 patients were treated with a carbapenem antibiotic. Included were 100 patients with and 111 patients without a documented or reported penicillin allergy. Within each group, subgroups of penicillin-allergic and penicillin-nonallergic patients were balanced equally between imipenem-cilastatin and meropenem. The incidence of patients with a reported or documented penicillin allergy experiencing an allergic-type reaction to a carbapenem was 11%, which is 5.2 times greater than the risk in patients who were reportedly not allergic to penicillin (P=.024). No difference in the occurrence of allergic-type reactions was observed between the 2 carbapenems.
William A Prescott; Daryl D DePestel; Jeffrey J Ellis; Randolph E Regal
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-03-26
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  38     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1102-7     Citation Subset:  IM    
University of Michigan Health System, Department of Pharmacy Services, Ann Arbor, MI 48109-0008, USA.
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MeSH Terms
Aged, 80 and over
Carbapenems / adverse effects*
Child, Preschool
Drug Hypersensitivity / epidemiology,  etiology*
Hypersensitivity / etiology
Middle Aged
Penicillins / adverse effects*
Reg. No./Substance:
0/Carbapenems; 0/Penicillins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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