Document Detail

Incidence of bacteraemia following fibreoptic bronchoscopy.
MedLine Citation:
PMID:  10573221     Owner:  NLM     Status:  MEDLINE    
Guidelines for antibiotic prophylaxis of infective endocarditis prior to fibreoptic bronchoscopy, are based on only five studies, which showed a bacteraemia rate of <1% among 291 patients studied. T his study was designed to expand the current data regarding the frequency of bacteraemia following fibreoptic bronchoscopy. Aerobic and anaerobic cultures of venous blood and of lavage fluid were drawn from 200 consecutive patients undergoing fibreoptic bronchoscopy without respiratory infection or antibiotic treatment prior to the procedure. The true bacteraemia rate was calculated after excluding probable "contaminated" blood cultures. A possible correlation between type of procedure performed during the bronchoscopy and occurrence of bacteraemia was investigated. Positive blood cultures were noted following 26 bronchoscopy examinations. Coagulase negative Staphylococcus was found in the cultures of 18 patients, coagulase positive Staphylococcus in 3 patients, nonhaemolytic streptococci and a Klebsiella species in 2 patients each, and beta haemolytic streptococcus in one patient. After exclusion of 13 "contaminated" specimens the bacteraemia rate was 6.5% (13/200 patients). This study showed a bacteraemia rate of 6.5%, significantly higher than previously recognized in a cohort of patients undergoing fibreoptic bronchoscopy without either pulmonary infection or an unusually high rate of invasive procedures. These findings should be taken into account in future evaluations of recommendations for antibiotic prophylaxis of endocarditis.
M Yigla; I Oren; L Bentur; A Solomonov; N Elias; R Altshuler; A E Rubin; F Lejbkowicz
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  14     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  789-91     Citation Subset:  IM    
Division of Pulmonary Medicine, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
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MeSH Terms
Aged, 80 and over
Antibiotic Prophylaxis
Bacteremia / epidemiology*,  etiology,  prevention & control
Bronchi / pathology
Bronchoalveolar Lavage Fluid / cytology,  microbiology
Bronchoscopy / adverse effects*
Child, Preschool
Fiber Optic Technology*
Klebsiella / isolation & purification
Klebsiella Infections / epidemiology*,  etiology,  prevention & control
Lung Diseases / diagnosis
Middle Aged
Staphylococcal Infections / epidemiology*,  etiology,  prevention & control
Staphylococcus / isolation & purification
Streptococcal Infections / epidemiology*,  etiology,  prevention & control
Streptococcus / isolation & purification
Reg. No./Substance:

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