Document Detail


Incidence of arterial cardiovascular events after venous thromboembolism: a systematic review and a meta-analysis.
MedLine Citation:
PMID:  20095999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SUMMARY BACKGROUND: Whether patients with unprovoked venous thromboembolism (VTE) have a higher risk of arterial cardiovascular events than the general population and patients with provoked VTE is a matter of debate. OBJECTIVE: To perform a systematic review and a meta-analysis aimed at assessing the risk of arterial cardiovascular events in patients with unprovoked VTE as compared with both patients with provoked VTE and controls. METHODS: A systematic search was performed. Studies reporting on (i) patients with confirmed VTE, (ii) a follow-up of at least 6 months and (iii) the incidence of arterial cardiovascular events (acute myocardial infarction and ischemic stroke) were included in the systematic review. Those studies reporting separate incidences of cardiovascular events in patients with unprovoked and provoked VTE or patients with unprovoked VTE and controls were included in the incidence rate meta-analysis. RESULTS: Overall, 17 studies were included in the systematic review. The weighted mean incidence of arterial cardiovascular events was 0.46% [95% confidence interval (CI) 0.34-0.59] and 0.35% (95% CI 0.24-0.49) per patient-year in patients with unprovoked and provoked VTE, respectively. Six studies were included in the meta-analysis. The risk of arterial cardiovascular events appeared to be higher in patients with unprovoked VTE than in controls [incidence rate ratio (IRR) 1.87, 95% CI 1.32-2.65] and than in patients with provoked VTE (IRR 1.86, 95% CI 1.19-2.89). CONCLUSIONS: Patients with unprovoked VTE have a higher risk of arterial cardiovascular events than patients with provoked VTE over long-term follow-up.
Authors:
C Becattini; M C Vedovati; W Ageno; F Dentali; G Agnelli
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2010-01-22
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  8     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  891-7     Citation Subset:  IM    
Affiliation:
Division of Internal and Cardiovascular Medicine & Stroke Unit, University of Perugia, Varese, Italy. cecilia.becattini@unipg.it
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MeSH Terms
Descriptor/Qualifier:
Arteries / pathology*
Cohort Studies
Humans
Incidence
Vascular Diseases / etiology*
Venous Thromboembolism / complications*

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