Document Detail

Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review.
MedLine Citation:
PMID:  19647839     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the incidence of apnea in infants hospitalized with respiratory syncytial virus (RSV) bronchiolitis and identify relevant risk factors from the available literature. STUDY DESIGN: A systematic search of available databases for studies reporting the rate of apnea in a consecutive cohort of infants hospitalized with RSV infection was performed. The overall incidence of apnea was extracted and analyzed in relation to preterm birth, age, and potentially confounding illnesses. RESULTS: The incidence of apnea in the study population of 5575 hospitalized patients with RSV ranged from a high of 23.8% to a low of 1.2%. Comparison of the cohort by term and preterm birth revealed an expected excess in apnea incidence in preterms, even in the absence of information about chronologic age. Many studies appeared to be confounded by the inclusion of impaired infants with neuromuscular disorders. CONCLUSIONS: Based on the available data, precisely quantifying the risk of apnea attributable to RSV infection is not possible. Factors intrinsic to the individual infants may account for a significant percentage of the apnea attributed to RSV. Recent studies have found a < 1% incidence of apnea with RSV in previously healthy term infants.
Shawn Ralston; Vanessa Hill
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2009-08-03
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-33     Citation Subset:  AIM; IM    
Department of Pediatrics, Division of Inpatient Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
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MeSH Terms
Apnea / diagnosis,  epidemiology*,  therapy
Bronchiolitis, Viral / diagnosis,  epidemiology*,  therapy
Cohort Studies
Combined Modality Therapy
Follow-Up Studies
Hospitalization / statistics & numerical data
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Respiratory Syncytial Virus Infections / diagnosis,  epidemiology*,  therapy
Risk Assessment
Severity of Illness Index
Survival Analysis
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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