Document Detail

Incidence of adenomatous hyperplasia in postmortem cirrhotic livers and study of cellular proliferative indices by light microscopy.
MedLine Citation:
PMID:  10063738     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adenomatous hyperplasia (AH) or dysplastic nodule in the liver is considered a preneoplastic lesion. A wide range in its incidence has been reported. AIMS: To study the incidence of AH nodules in autopsy cirrhotic livers and to carry out a comparative study of the cellular proliferative indices. MATERIALS: Retrospective study of 150 cases with cirrhosis of variable etiology at autopsy, over a 15-year period. METHODS: We identified AH on gross examination and studied the morphology. We compared cellular proliferative indices in AH nodules with other liver nodules by using PCNA monoclonal antibody and AgNOR. RESULTS: Alcohol was the commonest etiology (30%), followed by HBsAg positivity (38%). Most patients belonged to the 30-60 years age group, with male predominance. Sixty of the 150 livers showed AH nodules; there were one to four nodules, measuring 6 mm to 50 mm, per liver. 115/122 AH nodules were studied. Ordinary AH (OAH) was seen in 104 and atypical AH (AAH) in 11, with malignant focus (MF) in four. Associated hepatocellular carcinoma (HCC) was seen in 7 cases. A gradual increase in the proliferative indices from surrounding regenerating nodules (SRN) and OAH to AAH to AAH with MF to HCC was observed. In addition, AAH also showed relatively less reticulin fibers. CONCLUSION: The incidence of AH was 40%. In addition to the cellular proliferative indices, relatively less reticulin fibers could be a distinguishing feature for AAH from SRN, OAH and HCC.
K Vaiphei; U K Ghosh; R K Vasishta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  18     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    1999 Jan-Mar
Date Detail:
Created Date:  1999-04-07     Completed Date:  1999-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh.
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MeSH Terms
Adenoma / pathology*
Aged, 80 and over
Autopsy / methods
Hepatitis B Surface Antigens / analysis
Liver / pathology*
Liver Cirrhosis / pathology*
Liver Neoplasms / pathology*
Middle Aged
Nucleolus Organizer Region
Proliferating Cell Nuclear Antigen / analysis
Retrospective Studies
Sex Factors
Silver Staining
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Proliferating Cell Nuclear Antigen
Comment In:
Indian J Gastroenterol. 1999 Jan-Mar;18(1):2-4   [PMID:  10063736 ]

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