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Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review.
MedLine Citation:
PMID:  22859499     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundA recent increase in reports of acute hepatitis C virus infection (HCV) in HIV-infected and HIV-uninfected men who have sex with men (MSM), with the sole risk factor being sexual exposure, has led to routine screening and targeted prevention requests for this population; current evidence for this necessity is unclear.ObjectiveA systematic review was conducted to assess the incidence of HCV infection among studies conducted in HIV-positive and/or HIV-negative MSM to explore the implications for routine HCV screening.Data sourcesThe MEDLINE, EMBASE and BIOSYS databases were searched for the period January 2000 to May 2012, yielding 21 studies. Six conferences were hand-searched for the same period yielding four abstracts.Study selectionOnly studies in English presenting incidence rates of HCV and specifying HIV status were included.Data abstractionData were abstracted by two authors using predefined data fields. The STROBE checklist was used to assess study quality.Data synthesisData were divided into HIV-negative MSM and HIV-positive MSM subgroups, and HCV incidence density measurements were pooled. Using a DerSimonian-Laird random effects model, pooled incidence was 1.48/1000 person-years (95% CI 0.75 to 2.21) for the HIV-negative MSM subgroup. The HIV-positive MSM subgroup was at 4.1 times higher risk of acquiring HCV at 6.08/1000 person-years (95% CI 5.18 to 6.99). Studies directly comparing subgroups estimated a pooled risk difference of 3.45/1000 person-years (95% CI 1.63 to 5.27).ConclusionHIV-positive MSM were at higher risk for acute HCV infection than HIV-negative MSM, substantiating the need for routine screening initiatives. Insufficient evidence exists to warrant routine screening of HIV-negative MSM, except on a case-by-case basis, such as high-risk sexual behaviour.
Authors:
Sean Yaphe; Nikki Bozinoff; Rachel Kyle; Sushmita Shivkumar; Nitika Pant Pai; Marina Klein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-2
Journal Detail:
Title:  Sexually transmitted infections     Volume:  -     ISSN:  1472-3263     ISO Abbreviation:  Sex Transm Infect     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9805554     Medline TA:  Sex Transm Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Divisions of Infectious Diseases/Chronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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