Document Detail

Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997.
MedLine Citation:
PMID:  12715314     Owner:  NLM     Status:  MEDLINE    
Temporal trends in the incidence of opportunistic diseases (ODs) related to acquired immunodeficiency syndrome (AIDS) were studied during 1989-1997 in 1115 outpatients infected with human immunodeficiency virus (331 of whom had AIDS) in a hospital in Madrid, Spain. We analyzed the effect of adherence to antiretroviral therapy and Pneumocystis carinii pneumonia (PCP) prophylaxis on the incidence of OD. Diseases that showed a significant decreasing trend were esophageal candidiasis, pulmonary and extrapulmonary tuberculosis, and cerebral toxoplasmosis. Patients who adhered to antiretroviral therapy had a smaller risk of OD. Patients who adhered to PCP prophylaxis had a reduced risk of cerebral toxoplasmosis and PCP. A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease.
Francisco-Javier San-Andrés; Rafael Rubio; Jesús Castilla; Federico Pulido; Guillermo Palao; Inmaculada de Pedro; José-Ramón Costa; Angel del Palacio
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Publication Detail:
Type:  Journal Article     Date:  2003-04-14
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  36     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-25     Completed Date:  2003-05-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1177-85     Citation Subset:  IM    
Medicina Familiar y Comunitaria, Centro de Salud Potes, Guadalajara 19003, Spain.
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MeSH Terms
AIDS-Related Opportunistic Infections / epidemiology*
Anti-HIV Agents / therapeutic use
Antiretroviral Therapy, Highly Active
Cohort Studies
Guideline Adherence
HIV Infections / complications,  drug therapy*
Pneumonia, Pneumocystis / epidemiology
Reg. No./Substance:
0/Anti-HIV Agents

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