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The Incidence of Work-related Asthma-like Symptoms and Dust Exposure in Norwegian Smelters.
MedLine Citation:
PMID:  22517789     Owner:  NLM     Status:  Publisher    
AbstractWe have investigated the association between dust exposure and the incidence of work-related asthma-like symptoms (WASTH) among the employees in 18 Norwegian smelters.MethodsAll the employees were invited to participate in a five-year longitudinal study. The outcome of WASTH was defined as the combination of dyspnea and wheezing improving on rest days or vacation in an individual who had no asthma previously. Information about smoking and occupational status was obtained from a questionnaire. A job exposure matrix of total dust was developed. Multivariate data analyses were carried out using Cox regression. ResultsThe total follow-up time of the employees (n=2,476) was 8,469 years, and the median follow-up time for participants was 4.0 years. During the follow-up 91 employees developed WASTH, and the corresponding incidence rate for WASTH per 1000 person-years was 8.9 (95 % CI: 7.3 - 10.9). The risk ratio of WASTH increased significantly (p=0.0001) with dust exposure in the middle and high categories (1.0-2.9 and >3.0 mg/m3). Stratified analyses showed that the effect of current dust exposure varied with both previous exposure (PE) to dust and fumes (p=0.006) and airflow limitation (AFL) (p=0.033). The final analyses showed that the risk ratios for WASTH per 1 mg/m3 increase in current dust exposure were 1.1 (0.93-1.2), 1.4 (1.1-1.8), 1.6 (1.1-2.3) and 1.9 (1.2-3.0) for the categories (PE+/AFL-), (PE-/AFL-), (PE+/AFL+, and (PE-/AFL+).ConclusionIn conclusion, dust exposure was associated with an increased incidence of work-related asthma-like symptoms.
Vidar Søyseth; Helle Laier Johnsen; Paul K Henneberger; Johny Kongerud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-19
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical Department and Faculty Division, Akershus University Hospital, Lørenskog, Norway.
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