Document Detail

Incidence, Predictors and Outcomes of Congenital Diaphragmatic Hernia: A Population-Based Study of 32 Million Births in the United States.
MedLine Citation:
PMID:  24156638     Owner:  NLM     Status:  Publisher    
Abstract Objectives: To evaluate the incidence, risk factors and neonatal outcomes associated with a congenital diaphragmatic hernia (CDH). Study Design: We conducted a population-based cohort study using the CDC's Linked Birth-Infant Death and Fetal Death data files on all births and fetal deaths in the United States between 1995 and 2002. We estimated the yearly incidence of CDH and measured its adjusted effect on various outcomes using unconditional logistic regression analysis. Results: 32,145,448 births during the 8-year study period met the study's inclusion criteria. The incidence of CDH was 1.93/10,000 births. Risk factors for the development of CDH included fetal male gender [OR 1.12, 95% CI: 1.06, 1.17], maternal age beyond 40 [OR 1.51, 95% CI: 1.26, 1.80], Caucasian ethnicity [OR 1.15, 95% CI: 1.10, 1.21], smoking [OR 1.34, 95% CI: 1.22, 1.46] and alcohol use during pregnancy [OR 1.37, 95% CI: 1.05, 1.79]. As compared to fetuses with no CDH, fetuses with CDH were at an increased risk of preterm birth [OR 2.90, 95% CI: 2.72, 3.11], IUGR [OR 3.84, 95% CI: 3.51, 4.18], stillbirth [OR 9.65, 95% CI: 8.20, 11.37], and overall infant death [OR: 94.80, 95% CI: 88.78, 101.23]. The 1-year mortality was 45.89%. Conclusion: Congenital diaphragmatic hernia is strongly associated with an increased risk of adverse pregnancy, fetal and neonatal outcomes. These findings may be helpful in counselling pregnancies affected by CDH, and may aid in the understanding of the burden of this condition at the public health level.
Jacques Balayla; Haim A Abenhaim
Related Documents :
16675438 - Fine particulate matter (pm2.5) air pollution and selected causes of postneonatal infan...
23884968 - Breast-feeding initiation in women with pregestational diabetes mellitus.
9177988 - Sudden infant death and prevalence of whooping cough in the swedish and norwegian commu...
8496748 - Prevalence of medium-chain acyl-coenzyme a dehydrogenase deficiency in the sudden infan...
6700278 - The impact of prenatal care on birth weight. evidence from an international data set.
10459128 - Anetoderma of prematurity in association with electrocardiographic electrodes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-25
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, University of Montreal, Montreal, QC, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibrobla...
Next Document:  Hydrodynamic chromatography coupled with single particle-inductively coupled plasma mass spectrometr...